{"id":40909,"date":"2018-09-18T10:48:08","date_gmt":"2018-09-18T02:48:08","guid":{"rendered":"https:\/\/www.gene-optimal.com\/?p=40909"},"modified":"2019-08-16T10:02:17","modified_gmt":"2019-08-16T02:02:17","slug":"note-ngf","status":"publish","type":"post","link":"https:\/\/www.gene-optimal.com\/note-ngf\/","title":{"rendered":"\u7ec6\u80de\u56e0\u5b50\u5c0f\u7b14\u8bb0\u4e4bNGF"},"content":{"rendered":"<p>\u795e\u7ecf\u751f\u957f\u56e0\u5b50\uff08nerve gowth factor\uff0cNGF\uff09\u4e8e1953\u5e74\u88abLevi-Montalcini\u7b49\u53d1\u73b0\uff0c\u5c5e\u4e8e\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u5bb6\u65cf\uff0c\u80fd\u591f\u4fc3\u8fdb\u795e\u7ecf\u5143\u7684\u5206\u5316\uff0c\u7ef4\u6301\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\uff0c\u5176\u53d1\u73b0\u662f\u73b0\u4ee3\u751f\u7269\u5b66\u53d1\u5c55\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002\u4e3a\u6b64\uff0cLevi-Montalcini\u7b49\u57281986\u5e74\u88ab\u6388\u4e88\u8bfa\u8d1d\u5c14\u751f\u7406\u6216\u533b\u5b66\u5956\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-40913\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/levi2.jpg\" alt=\"\" width=\"479\" height=\"276\" srcset=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/levi2.jpg 479w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/levi2-200x115.jpg 200w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/levi2-150x86.jpg 150w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/levi2-300x173.jpg 300w\" sizes=\"(max-width: 479px) 100vw, 479px\" \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt; color: #595959;\">\u7ef4\u57fa\u767e\u79d1<\/span><\/p>\n<section class=\"\" data-role=\"paragraph\"><\/section>\n<section class=\"\" data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"8\" data-color=\"#374aae\" data-custom=\"#374aae\">\n<section data-brushtype=\"text\"><\/section>\n<section data-brushtype=\"text\"><\/section>\n<section class=\"\" data-brushtype=\"text\"><span style=\"color: #3366ff;\">NGF\u524d\u4f53\uff08proNGF\uff09\u53ca\u6210\u719fNGF<\/span><\/section>\n<\/section>\n<p>NGF\u5728\u4f53\u5185\u4ee5\u524d\u4f53\u5f62\u5f0f\u5408\u6210\uff0c\u524d\u4f53\u6c28\u57fa\u9178\u5e8f\u5217\u53ef\u5206\u4e3a\u4fe1\u53f7\u80bd\u548c\u6210\u719f\u80bd\u3002\u4fe1\u53f7\u80bd\u6709\u52a9\u4e8e\u86cb\u767d\u5206\u6ccc\uff1b\u6210\u719f\u80bd\u7ecf\u8fdb\u4e00\u6b65\u52a0\u5de5\u53ef\u751f\u6210\u5177\u6709\u751f\u7269\u5b66\u529f\u80fd\u7684NGF\u3002NGF\u94fe\u5185\u5171\u67096\u4e2a\u534a\u80f1\u6c28\u9178\u6b8b\u57fa\uff0c\u53ef\u5bf9\u5e94\u5f62\u62103\u5bf9\u94fe\u5185\u4e8c\u786b\u952e\uff0c\u4e8c\u786b\u952e\u7684\u5f62\u6210\u662fNGF\u5177\u6709\u6d3b\u6027\u7684\u5fc5\u8981\u6761\u4ef6\u3002\u81ea\u7531\u7684NH2\u672b\u7aef\u4e3aNGF\u7ed3\u5408\u53d7\u4f53\u6240\u5fc5\u9700\uff0c\u800cNGF-C\u672b\u7aef112\uff5e115\u4f4d\u6b8b\u57fa\u7684\u7a81\u53d8\u80fd\u591f\u660e\u663e\u5f71\u54cdNGF\u7ed3\u6784\u7684\u7a33\u5b9a\u6027\u53caNGF\u7684\u6d3b\u6027\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-40914\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf01.png\" alt=\"\" width=\"838\" height=\"354\" srcset=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf01.png 930w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf01-200x85.png 200w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf01-150x63.png 150w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf01-300x127.png 300w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf01-768x325.png 768w\" sizes=\"(max-width: 838px) 100vw, 838px\" \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt; color: #595959;\">NGF\u524d\u4f53\u53caNGF\u86cb\u767d\u6c28\u57fa\u9178\u5e8f\u5217<\/span><\/p>\n<section class=\"\" data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"8\" data-color=\"#374aae\" data-custom=\"#374aae\">\n<section data-brushtype=\"text\"><\/section>\n<section data-brushtype=\"text\"><\/section>\n<section class=\"\" data-brushtype=\"text\"><span style=\"color: #3366ff;\">NGF\u53d7\u4f53\u548c\u4fe1\u53f7\u901a\u8def<\/span><\/section>\n<\/section>\n<p>\u5728\u54fa\u4e73\u52a8\u7269\u4f53\u5185\u5b58\u57284\u79cd\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff0c\u5373NGF\u3001BDNF\u3001NT-3\u548cNT-4\uff0f5\uff0c\u5b83\u4eec\u901a\u8fc7\u7ed3\u54084\u79cd\u53d7\u4f53\uff08p75NTR\u3001TrkA\u3001TrkB\u53caTrkC\uff09\u53d1\u6325\u4f5c\u7528\u30024\u79cd\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u5747\u53ef\u7ed3\u5408p75NTR\u53d7\u4f53\uff0c 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TrkA\u53d7\u4f53\u901a\u8fc7PI3-Akt\u548cRas-MAP\u6fc0\u9176\u9014\u5f84\u4fc3\u8fdb\u795e\u7ecf\u7a81\u8d77\u7684\u751f\u957f\u548c\u5b58\u6d3b\u3002p75NTR\u53d7\u4f53\u901a\u8fc7\u795e\u7ecf\u9170\u80fa\u3001p53\u548cJNK\u9014\u5f84\u4ecb\u5bfc\u7ec6\u80de\u51cb\u4ea1\u3002\u5f53TrkA\u4e0ep75NTR\u5171\u8868\u8fbe\u65f6\uff0cp75NTR\u80fd\u591f\u589e\u52a0TrkA\u53d7\u4f53\u5bf9NGF\u7684\u7ed3\u5408\u529b\uff0c\u901a\u8fc7NF-kB\u548cRho\u4fe1\u53f7\u9014\u5f84\u4fc3\u8fdb\u795e\u7ecf\u7a81\u8d77\u7684\u751f\u957f\u548c\u5b58\u6d3b\uff1b\u7136\u800c\uff0c\u5982\u679cNGF\u4ec5\u4e0ep75NTR\u7ed3\u5408\uff0c\u4f1a\u4fc3\u8fdb\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-40915\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf02.png\" alt=\"\" width=\"760\" height=\"401\" srcset=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf02.png 760w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf02-200x106.png 200w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf02-150x79.png 150w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf02-300x158.png 300w\" sizes=\"(max-width: 760px) 100vw, 760px\" \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt; color: #595959;\">\u795e\u7ecf\u751f\u957f\u56e0\u5b50\u53ca\u5176\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u7c7b\u578b<\/span><\/p>\n<section class=\"\" data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"8\" data-color=\"#374aae\" data-custom=\"#374aae\">\n<section data-brushtype=\"text\"><\/section>\n<section data-brushtype=\"text\"><\/section>\n<section class=\"\" data-brushtype=\"text\"><span style=\"color: #3366ff;\">NGF\u529f\u80fd\u7814\u7a76<\/span><\/section>\n<\/section>\n<p><strong>\u53c2\u4e0e\u8840\u7ba1\u751f\u6210\uff1a<\/strong>\u5185\u76ae\u7ec6\u80de\u4e0e\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u4e0a\u6709NGF\u53d7\u4f53\uff0c\u80fd\u4e0eNGF\u7ed3\u5408\uff1bNGF\u8fd8\u80fd\u4fc3\u4f7f\u7ec6\u80de\u5206\u6cccVEGF\u3002<\/p>\n<p><strong>NGF\u4e0e\u514d\u75ab\u7ec6\u80de\u529f\u80fd\uff1a<\/strong>NGF\u4fc3\u8fdbB\u7ec6\u80de\u3001T\u7ec6\u80de\u7684\u589e\u6b96\u53caIgM\u3001IgA\u3001IgG\u7b49\u6297\u4f53\u7684\u751f\u6210\uff0c\u662f\u8bb0\u5fc6B\u7ec6\u80de\u7684\u81ea\u5206\u6ccc\u56e0\u5b50\u3002\u5728\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u53d7\u635f\u90e8\u4f4d\u7684NGF\u80fd\u534f\u8c03\u795e\u7ecf\u7ec6\u80de\u53ca\u514d\u75ab\u7ec6\u80de\uff0c\u6709\u52a9\u4e8e\u795e\u7ecf\u7cfb\u7edf\u7684\u4fee\u590d\u3002NGF\u80fd\u4fc3\u8fdb\u80a5\u5927\u7ec6\u80de\u5206\u5316\u53ca\u6210\u719f\u7b49\u7b49\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-40916\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf03.png\" alt=\"\" width=\"464\" height=\"548\" srcset=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf03.png 464w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf03-200x236.png 200w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf03-127x150.png 127w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/09\/ngf03-254x300.png 254w\" sizes=\"(max-width: 464px) 100vw, 464px\" \/><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: 10pt; color: #595959;\">NGF\u5bf9\u4e0d\u540c\u7c7b\u578b\u7ec6\u80de\u7684\u5f71\u54cd<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><strong>NGF\u5f71\u54cd\u795e\u7ecf\u5185\u5206\u6ccc\uff1a<\/strong>NGF\u6297\u4f53\u5904\u7406\u5e7c\u9f20\uff0c\u4f1a\u5bfc\u81f4\u7532\u72b6\u817a\u53d1\u80b2\u4e0d\u5168\u3001\u795e\u7ecf\u5185\u5206\u6ccc\u514d\u75ab\u7f3a\u4e4f\u7efc\u5408\u75c7\uff1b\u80fd\u901a\u8fc7\u94a0\u79bb\u5b50\u901a\u9053\u7684\u8868\u8fbe\u8c03\u63a7\u80f0\u5c9b\u7d20\u5206\u6ccc\uff0c\u5bf9\u7cd6\u5c3f\u75c5\u5bfc\u81f4\u7684\u5fc3\u810f\u7c7b\u75be\u75c5\u5177\u6709\u4fdd\u62a4\u529f\u80fd\u3002<\/p>\n<p><strong>NGF\u4e0e\u81ea\u8eab\u514d\u75ab\u75be\u75c5\uff1a<\/strong>\u795e\u7ecf\u751f\u957f\u56e0\u5b50\u5728\u6025\u6027\u548c\u6162\u6027\u75bc\u75db\u4e2d\u90fd\u8d77\u4e86\u5173\u952e\u4f5c\u7528\uff0c\u4e14\u4f1a\u968f\u7740\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\uff0c\u5f3a\u5236\u6027\u5173\u8282\u708e\uff0c\u9aa8\u5173\u8282\u708e\uff0c\u95f4\u8d28\u8180\u80f1\u708e\u7684\u53d1\u5c55\u800c\u589e\u591a\u3002\u9aa8\u5934\u7684\u4f24\u5bb3\u611f\u53d7\u5668\u53d7\u4f53\u539f\u808c\u7403\u86cb\u767d\u76f8\u5173\u6fc0\u9176A\uff08TrKA\uff09\u548c\u56e0\u708e\u75c7\u4ecb\u8d28\u523a\u6fc0\u91ca\u653e\u7684\u80a5\u5927\u7ec6\u80de\u53d7\u5230\u5230\u635f\u4f24\u6216\u75bc\u75db\u523a\u6fc0\uff0c\u800c\u91ca\u653e\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u03b2-\u795e\u7ecf\u751f\u957f\u56e0\u5b50\uff08NGF\uff09\uff0c\u6fc0\u6d3b\u7ec6\u80de\u5185\u6fc0\u9176\u4fe1\u53f7\u901a\u8def\uff0c\u75bc\u75db\u4fe1\u53f7\u6700\u7ec8\u4ece\u5916\u5468\u4f20\u9012\u81f3\u810a\u9ad3\u548c\u8111\u90e8\u3002Anti-NGF\u662f\u6cbb\u7597\u5173\u8282\u708e\u7c7b\u75be\u75c5\u7684\u6f5c\u5728\u836f\u7269\u3002\u800c\u5728\u795e\u7ecf\u7cfb\u7edf\u4e2d\u3002NGF\u80fd\u9632\u6b62\u81ea\u8eab\u514d\u75ab\u7684\u53d1\u751f\uff0c\u5bf9\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u5982\u8001\u5e74\u6027\u75f4\u5446\u3001\u8111\u53d1\u80b2\u4e0d\u826f\u3001\u5e15\u91d1\u68ee\u6c0f\u75c5\u7b49\u5177\u6709\u5177\u6709\u6539\u5584\u4f5c\u7528\u3002<\/p>\n<p>NGF\u529f\u80fd\u590d\u6742\uff0c\u534f\u8c03\u8840\u6db2\u5faa\u73af\u7cfb\u7edf\u3001\u514d\u75ab\u7cfb\u7edf\u3001\u795e\u7ecf\u7cfb\u7edf\u7b49\u7cfb\u7edf\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u82e5\u5176\u5e73\u8861\u88ab\u6253\u7834\uff0c\u5219\u4f1a\u5bfc\u81f4\u5185\u5206\u6ccc\u5931\u8c03\u3001\u81ea\u8eab\u514d\u75ab\u75c5\u7b49\u3002<\/p>\n<section class=\"\" data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"8\">\n<section data-brushtype=\"text\"><\/section>\n<section data-brushtype=\"text\"><\/section>\n<section class=\"\" data-brushtype=\"text\"><span style=\"color: #3366ff;\">\u5e02\u573a\u5e94\u7528<\/span><\/section>\n<\/section>\n<p>NGF\u76ee\u524d\u4e3b\u8981\u7528\u4e8e\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u7684\u6cbb\u7597\u3002\u9f20NGF\uff08mNGF\uff09\u4e0e\u4ebaNGF\uff08hNGF\uff09\u540c\u6e90\u6027\u8fbe90%\uff0c\u5e76\u4e14\u4ece\u9f20\u988c\u4e0b\u817a\u4e2d\u63d0\u53d6NGF\u7684\u5de5\u827a\u6bd4\u8f83\u7b80\u4fbf\uff0c\u63d0\u53d6\u6240\u5f97NGF\u6d3b\u6027\u8f83\u9ad8\uff0c\u56e0\u6b64\u9f20NGF\u6210\u4e3a\u7b2c\u4e00\u4e2a\u4e0a\u5e02\u7684NGF\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e34\u5e8a\u6cbb\u7597\u89c6\u795e\u7ecf\u635f\u4f24\u4ee5\u53ca\u4fc3\u8fdb\u795e\u7ecf\u635f\u4f24\u7684\u6062\u590d\uff0c\u7597\u6548\u663e\u8457\u3002\u793c\u6765\u548c\u8f89\u745e\u516c\u53f8\u5f00\u53d1\u4e86tanezumab\uff0c\u662f\u4e00\u79cdNGF\u6297\u4f53\uff0c\u80fd\u963b\u65ad\u795e\u7ecf\u7cfb\u7edf\u5bf9\u4e8e\u75db\u89c9\u7684\u4ea7\u751f\u8d77\u5230\u6b62\u75db\u4f5c\u7528\uff0c\u4f46\u5176\u836f\u7269\u5b89\u5168\u6027\u4ecd\u53d7\u8d28\u7591\uff0c\u76ee\u524d\u5904\u4e8e\u4e34\u5e8a\u4e09\u671f\u3002<\/p>\n<section class=\"\" data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"8\">\n<section data-brushtype=\"text\"><\/section>\n<section data-brushtype=\"text\"><\/section>\n<section class=\"\" data-brushtype=\"text\"><span style=\"color: #3366ff;\">NGF\u7684\u7ed9\u836f\u9014\u5f84<\/span><\/section>\n<\/section>\n<p>NGF\u4e3a\u6c34\u6eb6\u6027\uff0c\u4e14\u76f8\u5bf9\u5206\u5b50\u8d28\u91cf\u8f83\u5927\uff0c\u5728\u81ea\u7136\u72b6\u6001\u4e0b\u51e0\u4e4e\u4e0d\u80fd\u900f\u8fc7\u8840\u8111\u5c4f\u969c\u3002\u76ee\u524d\u4e0a\u5e02\u7684\u9f20\u988c\u4e0b\u817a\u63d0\u53d6\u7684NGF\u4ee5\u808c\u8089\u6ce8\u5c04\u65b9\u5f0f\u7ed9\u836f\uff0c\u65e0\u6cd5\u7a7f\u900f\u8840\u773c\u5c4f\u969c\u548c\u8840\u8111\u5c4f\u969c\uff0c\u7528\u4e8e\u6cbb\u7597\u773c\u90e8\u75be\u75c5\u548c\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u3002\u901a\u8fc7\u66f4\u6539\u7ed9\u836f\u9014\u5f84\u4f7fNGF\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\u548c\u8840\u773c\u5c4f\u969c\u7684\u7814\u7a76\u4e3b\u8981\u5982\u4e0b\uff1a<\/p>\n<section class=\"\" data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"5\" data-color=\"#374aae\" data-custom=\"#374aae\" data-width=\"90%\">\n<section class=\"\">\u2460\u8111\u5ba4\u6ce8\u5c04\uff1b\u2461\u5c40\u90e8\u7ed9\u836f\u7f13\u91ca\uff1b\u2462\u8f7d\u4f53\u5076\u8054\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\uff08NGF\u5076\u8054\u6297\u8f6c\u94c1\u86cb\u767d\u53d7\u4f53\u6297\u4f53\uff09\uff1b\u2463\u76f4\u63a5\u5c06NGF\u57fa\u56e0\u5bfc\u5165\u8111\u5185\u7279\u5b9a\u7ec6\u80de\u4e2d\uff1b\u2464\u5c06\u8868\u8fbeNGF\u7684\u8f6c\u57fa\u56e0\u7ec6\u80de\u79fb\u690d\u5165\u8111\u5185\u8868\u8fbeNGF\u3002<\/p>\n<p>\u5176\u4ed6\u7ed9\u836f\u65b9\u6cd5\u8fd8\u6709\uff1aNGF-PBCA\u7eb3\u7c73\u7c92\u3001\u9759\u8109\u5feb\u901f\u6ef4\u6ce8\u7518\u9732\u9187\u53ef\u9006\u6027\u6682\u65f6\u5f00\u653e\u8840\u8111\u5c4f\u969c\u3001NGF-\u8102\u8d28\u4f53\u3001NGF\u6ef4\u773c\u6db2\u7b49<\/p>\n<\/section>\n<\/section>\n<section class=\"\" data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"8\">\n<section data-brushtype=\"text\"><\/section>\n<section data-brushtype=\"text\"><\/section>\n<section class=\"\" data-brushtype=\"text\"><span style=\"color: #3366ff;\">NGF\u4e34\u5e8a\u7814\u7a76<\/span><\/section>\n<\/section>\n<p><strong>\u4eba<\/strong><strong>NGF<\/strong><strong>\u57fa\u56e0\u7597\u6cd5\u4e34\u5e8a\u8bd5\u9a8c<\/strong>\uff1a\u5bf9\u4e8e\u5178\u578b\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u5982\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08Alzheimerdisease\uff0cAD\uff09\uff0cNGF\u662f\u6f5c\u5728\u7684\u6cbb\u7597\u836f\u7269\u3002AD\u7684\u53d1\u751f\u4f1a\u5bfc\u81f4\u57fa\u5e95\u524d\u80c6\u78b1\u80fd\u795e\u7ecf\u5143\u7684\u9000\u53d8\uff0c\u964d\u4f4e\u76ae\u8d28\u80c6\u78b1\u80fd\u795e\u7ecf\u9012\u8d28\u7684\u4f20\u9012\u529f\u80fd\uff0c\u800c\u5728\u57fa\u5e95\u6838\u4e2d\uff0cTrkA\u548cp75NTR\u4e13\u6709\u5730\u5b58\u5728\u4e8e\u80c6\u78b1\u795e\u7ecf\u5143\uff0c\u56e0\u6b64\uff0c\u53ef\u4ee5\u901a\u8fc7NGF\u7ef4\u6301\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\uff0c\u589e\u5f3a\u76ae\u8d28\u80c6\u78b1\u80fd\u795e\u7ecf\u9012\u8d28\u7684\u4f20\u9012\u529f\u80fd\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u88ab\u6279\u51c6\u7528\u4e8eAD\u6cbb\u7597\u76845\u79cd\u836f\u54c1\u4e2d\uff0c\u67094\u79cd\u4e3a\u4e59\u9170\u80c6\u78b1\u916f\u9176\u6291\u5236\u5242\uff0c\u8fd9\u4e9b\u5236\u5242\u53ea\u80fd\u4fc3\u4f7f\u6781\u5c11\u6570\u7684AD\u521d\u671f\u60a3\u8005\u6539\u5584\u8ba4\u77e5\u80fd\u529b\uff1b\u53e6\u5916\u4e00\u79cd\u836f\u7269\u4e3aNMDA\u53d7\u4f53\u975e\u7ade\u4e89\u578b\u6fc0\u52a8\u5242\uff0c\u901a\u8fc7NGF\u4f5c\u7528\u51cf\u5c11\u57fa\u5e95\u524d\u80c6\u78b1\u80fd\u795e\u7ecf\u5143\u7ec6\u80de\u7684\u6b7b\u4ea1\uff0c\u4e5f\u662f\u6cbb\u7597AD\u7684\u4e00\u79cd\u9014\u5f84\uff0c\u4f46\u662f\u6210\u719f\u7684NGF\u86cb\u767d\u4e0d\u80fd\u901a\u8fc7\u8840\u8111\u5c4f\u969c\uff0c\u8fd9\u662f\u4e34\u5e8a\u5e94\u7528\u7684\u4e00\u4e2a\u969c\u788d\u3002<\/p>\n<p>Mandel\u901a\u8fc7\u7acb\u4f53\u5b9a\u4f4d\u6ce8\u5c04\u5c06\u8868\u8fbe\u4ebaNGF\u7684AAV2\u8f7d\u4f53\u5bfc\u5165\u5230\u57fa\u5e95\u6838\u4e2d\uff0c\u7528\u4e8e\u6cbb\u7597AD\uff0c\u5df2\u5b8c\u6210\u2160\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6b63\u5728\u8fdb\u884c\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u901a\u8fc7\u957f\u65f6\u95f4\u7684\u7814\u7a76\u8868\u660e\uff0c\u8be5\u65b9\u6cd5\u6bd4\u8f83\u5b89\u5168\uff0c\u526f\u4f5c\u7528\u5c0f\uff0c\u4e34\u5e8a\u7814\u7a76\u4e2d\u7684AD\u60a3\u8005\u7684\u8ba4\u77e5\u80fd\u529b\u4ee5\u53ca\u5927\u8111\u76ae\u8d28\u4ee3\u8c22\u5747\u6709\u6539\u5584\uff0c\u4f46\u662f\u53ef\u80fd\u4f1a\u5b58\u5728\u5c40\u90e8NGF\u8fc7\u91cf\u8868\u8fbe\u7684\u6f5c\u5728\u95ee\u9898\u3002<\/p>\n<p><strong>\u91cd\u7ec4\u4eba<\/strong><strong>NGF<\/strong><strong>\u86cb\u767d\u4e34\u5e8a\u8bd5\u9a8c<\/strong>\uff1a\u91cd\u7ec4\u4ebaNGF\u7528\u4e8e\u6cbb\u7597HIV\u5f15\u8d77\u7684\u611f\u89c9\u795e\u7ecf\u75c5\u53d8\u7684\u2161\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u663e\u793a\uff0cNGF\u80fd\u6709\u6548\u7f13\u89e3\u795e\u7ecf\u6027\u5934\u75bc\u3002\u672c\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u91c7\u53d6\u53cc\u76f2\u6cd5\uff0c\u4f46\u7531\u4e8e\u5c40\u90e8\u6ce8\u5c04NGF\u5f15\u8d77\u7684\u5c40\u90e8\u75bc\u75db\uff0c\u5bfc\u81f439%\u7684\u53d7\u8bd5\u8005\u7834\u76f2\u3002<\/p>\n<p>\u91cd\u7ec4\u4ebaNGF\u7528\u4e8e\u6cbb\u7597\u7cd6\u5c3f\u75c5\u5f15\u8d77\u7684\u795e\u7ecf\u75c5\u53d8\u7684\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bc1\u660e\u4e86\u91cd\u7ec4\u4ebaNGF\u7684\u5b89\u5168\u6027\uff0c\u4f46\u5374\u672a\u80fd\u8bc1\u660e\u5176\u6709\u6548\u6027\uff0c\u6700\u7ec8\u5ba3\u544a\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5931\u8d25\u3002\u5931\u8d25\u7684\u539f\u56e0\u53ef\u80fd\u662f\u7ed9\u836f\u5242\u91cf\u4e0d\u8db3\uff0c\u5b89\u6170\u5242\u8d77\u5230\u4e86\u5f88\u597d\u7684\u4f5c\u7528\uff0c\u4e24\u6b21\u8bd5\u9a8c\u53d7\u8bd5\u4eba\u7fa4\u7ed3\u6784\u7ec4\u6210\u4e0d\u540c\uff0c\u4ee5\u53ca\u6ce8\u5c04\u7528\u91cd\u7ec4\u4ebaNGF\u914d\u65b9\u7684\u533a\u522b\u7b49\u9020\u6210\u3002<\/p>\n<p><strong>NGF<\/strong><strong>\u7684\u4e34\u5e8a\u5e94\u7528<\/strong>\uff1a\u9f20\u988c\u4e0b\u817a\u63d0\u53d6\u7684NGF\u80fd\u591f\u6709\u6548\u6cbb\u7597\u5916\u5468\u795e\u7ecf\u635f\u4f24\uff0c\u6301\u7eed\u6027\u89d2\u819c\u7f3a\u635f\u3001\u89d2\u819c\u6e83\u75a1\u3001\u5e72\u71e5\u6027\u89d2\u819c\u7ed3\u819c\u708e\u3001\u767d\u5185\u969c\u672f\u540e\u6108\u5408\u3001\u9752\u5149\u773c\u7b49\uff0c\u5e76\u6210\u529f\u6cbb\u6108\u9f3b\u54bd\u764c\u653e\u7597\u5f15\u8d77\u7684\u653e\u5c04\u6027\u989e\u53f6\u574f\u6b7b\u3002\u9885\u8111\u635f\u4f24 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