{"id":40937,"date":"2018-10-15T09:51:24","date_gmt":"2018-10-15T01:51:24","guid":{"rendered":"https:\/\/www.gene-optimal.com\/?p=40937"},"modified":"2019-08-16T10:01:08","modified_gmt":"2019-08-16T02:01:08","slug":"note-kgf","status":"publish","type":"post","link":"https:\/\/www.gene-optimal.com\/note-kgf\/","title":{"rendered":"\u7ec6\u80de\u56e0\u5b50\u5c0f\u7b14\u8bb0\u4e4bKGF"},"content":{"rendered":"<p>\u89d2\u8d28\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08keratinocyte growth factor\uff0cKGF\uff09\u53c8\u79f0FGF-7,\u662f\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08FGFs\uff09\u5bb6\u65cf\u6210\u5458\u4e4b\u4e00\uff0c\u6700\u65e9\u7531Rubin\u7b49\u4eba\u4e8e1989\u5e74\u4ece\u4eba\u80da\u80ce\u80ba\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u57f9\u517b\u6db2\u4e2d\u5206\u79bb\u7eaf\u5316\u83b7\u5f97\uff0c\u5206\u5b50\u91cf\u4e3a26-28KD\u3002KGF\u7531\u591a\u79cd\u6765\u6e90\u7684\u95f4\u8d28\u7ec6\u80de\u5206\u6ccc\uff0c\u4f5c\u7528\u9776\u7ec6\u80de\u4e3a\u4e0a\u76ae\u7ec6\u80de\uff0c\u80fd\u4fc3\u8fdb\u4e0a\u76ae\u7ec6\u80de\u7684\u589e\u6b96\u548c\u751f\u957f\uff0c\u4e0e\u4e0a\u76ae\u521b\u4f24\u6108\u5408\u3001\u80da\u80ce\u53d1\u80b2\u3001\u80bf\u7624\u5f62\u6210\u4e0e\u53d1\u5c55\u3001\u514d\u75ab\u91cd\u5efa\u7b49\u5173\u7cfb\u5bc6\u5207\u3002\u4e0b\u9762\u6211\u4eec\u5c06\u8be6\u7ec6\u4ecb\u7ecdKGF\u57fa\u56e0\u53ca\u86cb\u767d\u4fe1\u606f\u3001\u53d7\u4f53\u3001\u4fe1\u53f7\u901a\u8def\u3001\u76f8\u5173\u75be\u75c5\u53ca\u5e02\u573a\u5e94\u7528\u3002<\/p>\n<h4><span style=\"color: #3366ff;\">KGF\u57fa\u56e0\u53ca\u86cb\u767d\u76f8\u5173\u4fe1\u606f<\/span><\/h4>\n<p>KGF\u57fa\u56e0\u4f4d\u4e8e15\u53f7\u67d3\u8272\u4f53\uff0815q15-15q21.1\uff09\uff0c\u5305\u62ec3\u4e2a\u5916\u663e\u5b50\u548c2\u4e2a\u5185\u542b\u5b50\uff1b\u542f\u52a8\u5b50\u533a\u4f4d\u4e8e-225\/+190\u533a\uff0c\u5177\u5178\u578b\u7684TATA\uff0831bp\uff09\u548cCCAAT\uff0850bp\uff09\uff0c\u4e3a\u987a\u5f0f\u4f5c\u7528\u8c03\u63a7\u56e0\u5b50\u5982IL6\u3001\u6bdb\u5589\u7d20\u7b49\u63d0\u4f9b\u7ed3\u5408\u4f4d\u70b9\uff0c1503\/-775\u533a\u5b58\u5728\u6291\u5236\u56e0\u5b50\u7684\u7ed3\u5408\u90e8\u4f4d\u3002\u4eba9\u53f7\u67d3\u8272\u4f53\u4e0a\u5b58\u57285\u4e2a\u91cd\u590dKGF\u57fa\u56e0\u5e8f\u5217\uff0c\u4f46\u662f\u4e0d\u80fd\u751f\u6210\u6709\u529f\u80fd\u7684KGF\u86cb\u767d\uff1b21\u53f7\u67d3\u8272\u4f53\u4e0a\u6709KGF\u76f8\u4f3c\u57fa\u56e0\u5e8f\u5217\uff0c\u529f\u80fd\u4e0d\u660e\u3002<\/p>\n<p>KGF\u57fa\u56e0\u8f6c\u5f55\u540e\u53ef\u5f97\u5230\u4e00\u4e2a3.853kb\u7684mRNA\uff0c\u7ffb\u8bd1\u540e\u751f\u6210\u7531194\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\u7684\u4ebaKGF\u86cb\u767d\uff0c\u53ef\u5206\u4e3a\u4fe1\u53f7\u80bd\u3001\u6210\u719f\u80bd\u4e24\u90e8\u5206\u3002KGF\u4fe1\u53f7\u80bd\u90e8\u5206\u5b58\u6709\u4e0e\u5929\u51ac\u6c28\u9178\u7ed3\u5408\u7684\u7cd6\u57fa\u5316\u4f4d\u70b9\uff0cKGF\u6210\u719f\u80bd\u4e0e\u809d\u7d20\u3001\u786b\u9178\u4e59\u9170\u809d\u7d20\u86cb\u767d\u591a\u7cd6\u6709\u9ad8\u5ea6\u4eb2\u548c\u529b\u3002\u5728\u5927\u80a0\u6746\u83cc\u4e2d\u8fc7\u8868\u8fbe\u7684\u91cd\u7ec4KGF\u6d3b\u6027\u7ea6\u4e3a\u5929\u7136\u86cb\u767d\u768410\u500d\uff0c\u53ef\u80fd\u4e0e\u91cd\u7ec4KGF\u672a\u88ab\u7cd6\u57fa\u5316\u6709\u5173\u3002KGF\u80bd\u94fe\u524d23\u4e2a\u6c28\u57fa\u9178\u7f3a\u5931\u4e0d\u5f71\u54cd\u5176\u4fc3\u6709\u4e1d\u5206\u88c2\u6d3b\u6027\uff0c\u800c24-29\u6bb5\u7684\u6c28\u57fa\u9178\u6b8b\u57fa\u5bf9\u5176\u751f\u7269\u5b66\u6d3b\u6027\u6709\u91cd\u8981\u5f71\u54cd\uff0cKGF 122-132\u6bb5\u662fKGF\u53d7\u4f53\u7684\u7279\u5f02\u6027\u7ed3\u5408\u4f4d\u70b9\u3002KGF\u5c5e\u4e8eFGF\u5bb6\u65cf\uff0c\u53c8\u79f0FGF-7\uff0c\u4e0eFGF\u5176\u4ed6\u5bb6\u65cf\u86cb\u767d\u7684\u540c\u6e90\u533a\u57df\u5305\u62ec\u7fa7\u57fa\u7aef2\/3 KGF\u7f16\u7801\u7247\u6bb5\uff1b\u4f46KGF\u6709\u660e\u663e\u7684\u4fe1\u53f7\u80bd\u7ed3\u6784\uff0c\u8fd9\u662fFGF\u5bb6\u65cfaFGF\u3001bFGF\u7b49\u6240\u4e0d\u5177\u6709\u7684\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-40938\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/fig-1.jpg\" alt=\"\" width=\"700\" height=\"99\" srcset=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/fig-1.jpg 700w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/fig-1-200x28.jpg 200w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/fig-1-150x21.jpg 150w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/fig-1-300x42.jpg 300w\" sizes=\"(max-width: 700px) 100vw, 700px\" \/><\/p>\n<p style=\"text-align: center;\"><span style=\"color: #808080;\">KGF\u6c28\u57fa\u9178\u5e8f\u5217\u4fe1\u606f<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u5929\u7136KGF\u7684\u7a33\u5b9a\u6027\u5dee\u4e8e\u5176\u4ed6\u5bb6\u65cf\u6210\u5458\uff0c\u6d3b\u6027\u6613\u53d7\u73af\u5883\u5f71\u54cd\uff0c\u751f\u7269\u534a\u8870\u671f\u77ed\uff0c\u5e76\u4e14\u7f3a\u4e4f\u7ec4\u7ec7\u9009\u62e9\u6027\u3002\u572850\u2103\u5b75\u80b210 min\u6d3b\u6027\u4e0d\u53d7\u5f71\u54cd\uff0c60\u2103\u5b75\u80b210 min\u6d3b\u6027\u964d\u4f4e68%\uff0c100\u2103\u5b75\u80b23 min\u540e\u5219\u4e0d\u80fd\u68c0\u6d4b\u5230\u6d3b\u6027\u3002KGF\u57280.5 mol\/L \u4e59\u9178\u4e2d\u5ba4\u6e29\u653e\u7f6e60 min\uff0c\u6d3b\u6027\u4e0b\u964d14%\u3002KGF\u5e94\u7528\u4e8e\u521b\u9762\uff0c\u6613\u53d7\u521b\u9762\u86cb\u767d\u9176\u7684\u5f71\u54cd\uff0c\u7a33\u5b9a\u6027\u8f83\u5dee\u3002<\/p>\n<h4><span style=\"color: #3366ff;\">KGF\u53d7\u4f53\u53ca\u4fe1\u53f7\u901a\u8def<\/span><\/h4>\n<p>KGF\u53d7\u4f53\uff08KGF receptor\uff0cKGFR\uff09\u662f\u4e00\u79cd\u8868\u8fbe\u4e8e\u4e0a\u76ae\u7ec6\u80de\u7684\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\uff0c\u7531FGF\u53d7\u4f532\uff08FGF receptor 2\uff0cFGFR-2\uff09\u57fa\u56e0\u7f16\u7801\uff0c\u4e3aFGFR-2\u7684\u526a\u63a5\u5f02\u53d8\u4f53FGFR-2-III b\uff0c\u662fKGF\u60df\u4e00\u53ef\u7ed3\u5408\u7684\u9ad8\u4eb2\u548c\u529b\u53d7\u4f53\u3002KGFR\u7684\u7ed3\u6784\u5305\u62ec\u7ec6\u80de\u5916\u6bb5\u3001\u8de8\u819c\u533a\u3001\u7ec6\u80de\u5185\u6bb53\u90e8\u5206\u3002Miki\u7b49\u7814\u7a76\u53d1\u73b0KGFR\u7ec6\u80de\u5916\u6bb5\u9664\u542b\u6709\u4fe1\u53f7\u80bd\u5916\uff0c\u5728N\u7aef\u5927\u7ea650\u4e2a\u6c28\u57fa\u9178\u5904\u5305\u542b3\u4e2a\u514d\u75ab\u7403\u86cb\u767d\u6837\u7ed3\u6784\u57df\uff0c\u6839\u636e\u86cb\u767d\u6837\u7ed3\u6784\u57df\u7684\u4e0d\u540c\u53c8\u53ef\u5206\u4e3a\u4e24\u79cd\uff0c\u4e00\u79cd\u4e3a\u5728Ig I\u3001Ig II\u7ed3\u6784\u57df\u4e4b\u95f4\u542b\u6709\u4e00\u6bb5\u9178\u6027\u6c28\u57fa\u9178\u5e8f\u5217\uff08\u4e3b\u8981\u662f\u5929\u95e8\u51ac\u6c28\u9178\u6216\u8c37\u6c28\u9178\uff09\uff0c\u53e6\u4e00\u79cd\u4e0d\u542bIg I\u548c\u9178\u6027\u6c28\u57fa\u9178\u5e8f\u5217\uff0c\u4f46\u4e24\u79cdKGFR\u5177\u6709\u540c\u6837\u7ed3\u5408\u914d\u4f53\u7684\u80fd\u529b\uff0c\u63d0\u793aIg I\u7ed3\u6784\u57df\u5e76\u4e0d\u53c2\u4e0e\u914d\u4f53\u7ed3\u5408\u3002KGFR\u548cFGFR-2\u662f\u540c\u4e00\u57fa\u56e0\u7f16\u7801\u7684\u4e0d\u540c\u4ea7\u7269\uff0c\u7ed3\u6784\u6781\u5176\u76f8\u4f3c\uff0c\u4f46\u5728Ig III\u7fa7\u57fa\u7aef\u768449\u4e2a\u6c28\u57fa\u9178\u5904\u5219\u6709\u660e\u663e\u4e0d\u540c\uff0c\u51b3\u5b9a\u4e86KGFR\u7ed3\u5408\u914d\u4f53\u7684\u7279\u5f02\u6027\u3002<\/p>\n<p>FGF\u4e0eFGFR\u53d7\u4f53\u7ed3\u5408\u540e\u6fc0\u6d3b\u7684\u7ecf\u5178\u4fe1\u53f7\u901a\u8def\u53ef\u5206\u4e3a3\u7c7b\uff1aRAS\/MAPK\u3001PI3K\/AKT\u3001PLC\u03b3\/PKC\uff0c\u53c2\u4e0e\u7ec6\u80de\u590d\u5236\u3001\u5206\u5316\u3001\u8fc1\u79fb\u7b49\u8fc7\u7a0b\u3002KGFR\u4fe1\u53f7\u901a\u8def\u6709\u4e9b\u4e0eFGFR\u4fe1\u53f7\u901a\u8def\u76f8\u540c\uff0c\u5982\u901a\u8fc7ERK\/Runx2\u901a\u8def\u4fc3\u8fdb\u80da\u80ce\u5e72\u7ec6\u80de\u5411\u6210\u9aa8\u7ec6\u80de\u5206\u5316\uff0c\u901a\u8fc7MAPK\u4fe1\u53f7\u901a\u8def\u53c2\u4e0e\u963f\u7c73\u6bcd\u7ec6\u80de\u7624\u7684\u590d\u5236\uff0c\u901a\u8fc7STAT11\/IRF1\uff08IRF2\uff09\u4fe1\u53f7\u901a\u8def\u4e0a\u8c03IL-7\u7684\u8868\u8fbe\uff0c\u901a\u8fc7PI3K\u53caJNK\/SREBP-1\u4fe1\u53f7\u901a\u8def\u4fc3\u8fdb\u8102\u7c7b\u5408\u6210\u7b49\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-40939\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/fig-2a.jpg\" alt=\"\" width=\"500\" height=\"569\" srcset=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/fig-2a.jpg 500w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/fig-2a-200x228.jpg 200w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/fig-2a-132x150.jpg 132w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/fig-2a-264x300.jpg 264w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/p>\n<p style=\"text-align: center;\"><span style=\"color: #808080;\">FGF-FGFR\u4fe1\u53f7\u901a\u8def<\/span><\/p>\n<p>&nbsp;<\/p>\n<h4><span style=\"color: #3366ff;\">KGF\u529f\u80fd\u4e0e\u75be\u75c5<\/span><\/h4>\n<p>KGF\u7684\u8868\u8fbe\u4ec5\u9650\u4e8e\u95f4\u8d28\u7ec6\u80de\uff0c\u800c\u4ed6\u7684\u53d7\u4f53\u5219\u662f\u5728\u4e0a\u76ae\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u627f\u62c5\u95f4\u8d28\u7ec6\u80de-\u4e0a\u76ae\u7ec6\u80de\u95f4\u7684\u4fe1\u53f7\u4f20\u9012\u529f\u80fd\u3002KGF\u4f5c\u7528\u4e8e\u4e0a\u76ae\u7ec6\u80de\u540e\u80fd\u4fc3\u8fdb\u4e0a\u76ae\u7ec6\u80de\u7684\u589e\u6b96\uff0cKGF\u523a\u6fc0\u89d2\u8d28\u7ec6\u80deDNA\u5408\u6210\u7684\u80fd\u529b\u6bd4\u8f6c\u5316\u751f\u957f\u56e0\u5b50TGF-\u03b1\u548c\u8868\u76ae\u751f\u957f\u56e0\u5b50\u5f3a2-10\u500d\u3002\u9f20\u3001\u732a\u3001\u5154\u7b49\u76ae\u80a4\u635f\u4f24\u6a21\u578b\u8868\u660eKGF\u5728\u76ae\u80a4\u53d7\u635f\u65f6\u8868\u8fbe\u91cf\u5feb\u901f\u5347\u9ad8\uff0c\u4fc3\u8fdb\u4e0a\u76ae\u7ec6\u80de\u589e\u6b96\u53ca\u76ae\u80a4\u4e0a\u76ae\u5316\uff0c\u52a0\u5f3a\u76ae\u80a4\u6bdb\u56ca\u548c\u76ae\u8102\u817a\u7684\u524d\u4f53\u7ec6\u80de\u589e\u6b96\u548c\u5206\u5316\u3002\u65f6\u95f4\u4e0a\u6765\u770b\uff0cKGF\u5728\u76ae\u80a4\u53d7\u635f\u540e\u7ef4\u63017\u5929\u5de6\u53f3\uff0c\u8be5\u65f6\u95f4\u6bb5\u6b63\u662f\u76ae\u80a4\u6108\u5408\u65f6\u95f4\uff0cKGF\u53d7\u4f53KGFR\u5219\u4ece\u76ae\u80a4\u53d7\u635f\u7684\u7b2c8-9\u5929\u5f00\u59cb\u5feb\u901f\u8f6c\u5f55\u7ffb\u8bd1\u3002\u6b64\u5916\uff0cKGF\u5728\u9aa8\u9abc\u808c\u7ec6\u80de\u3001\u5fc3\u808c\u7ec6\u80de\u3001\u5375\u6ce1\u3001\u7cbe\u56ca\u817a\u3001\u524d\u5217\u817a\u7b49\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u8d77\u7740\u91cd\u8981\u529f\u80fd\u3002<\/p>\n<p>\u65e2\u7136KGF\u7279\u5f02\u4f5c\u7528\u4e8e\u4e0a\u76ae\u7ec6\u80de\uff0c\u90a3\u4e9b\u4e0e\u4e0a\u76ae\u7ec6\u80de\u6709\u5173\u7684\u75be\u75c5\u662f\u5426\u53ef\u7528KGF\u6216KGF\u6297\u4f53\u6cbb\u7597\u5462\uff1f<\/p>\n<p>KGF\u4e0e\u80ba\u6c34\u80bf\uff1a\u80ba\u6c34\u80bf\u662f\u6307\u7531\u4e8e\u67d0\u79cd\u539f\u56e0\u5f15\u8d77\u80ba\u5185\u7ec4\u7ec7\u6db2\u7684\u751f\u6210\u548c\u56de\u6d41\u5e73\u8861\u5931\u8c03\uff0c\u4f7f\u5927\u91cf\u7ec4\u7ec7\u6db2\u5728\u5f88\u77ed\u65f6\u95f4\u5185\u4e0d\u80fd\u88ab\u80ba\u6dcb\u5df4\u548c\u80ba\u9759\u8109\u7cfb\u7edf\u5438\u6536\uff0c\u4ece\u80ba\u6bdb\u7ec6\u8840\u7ba1\u5185\u5916\u6e17\uff0c\u79ef\u805a\u5728\u80ba\u6ce1\u3001\u80ba\u95f4\u8d28\u548c\u7ec6\u5c0f\u652f\u6c14\u7ba1\u5185\uff0c\u4ece\u800c\u9020\u6210\u80ba\u901a\u6c14\u4e0e\u6362\u6c14\u529f\u80fd\u4e25\u91cd\u969c\u788d\u3002\u5728\u4e34\u5e8a\u4e0a\u8868\u73b0\u4e3a\u6781\u5ea6\u7684\u547c\u5438\u56f0\u96be\uff0c\u7aef\u5750\u547c\u5438\uff0c\u53d1\u7ec0\uff0c\u5927\u6c57\u6dcb\u6f13\uff0c\u9635\u53d1\u6027\u54b3\u55fd\u4f34\u5927\u91cf\u767d\u8272\u6216\u7c89\u7ea2\u8272\u6ce1\u6cab\u75f0\uff0c\u53cc\u80ba\u5e03\u6ee1\u5bf9\u79f0\u6027\u6e7f\u5570\u97f3\u3002\u9ad8\u8840\u538b\u3001\u5fc3\u808c\u6897\u585e\u3001\u5fc3\u74e3\u819c\u75c5\u5f15\u8d77\u7684\u5fc3\u810f\u529f\u80fd\u4e0d\u5168\u3001\u80ba\u708e\u3001\u80ba\u6813\u585e\u3001\u4f11\u514b\u3001\u9885\u5185\u75c5\u53d8\u7b49\u90fd\u80fd\u5bfc\u81f4\u80ba\u6c34\u80bf\u3002\u5b9e\u9a8c\u8868\u660eKGF\u53ef\u80fd\u901a\u8fc7\u4e0a\u8c03Na+-K+\u79bb\u5b50\u901a\u9053\u7684\u8868\u8fbe\uff0c\u4fc3\u8fdbNa+-K+\u79bb\u5b50\u901a\u9053\u7684\u8de8\u4e0a\u76ae\u8fd0\u8f93\uff0c\u4fc3\u8fdb\u80ba\u6025\u6027\u635f\u4f24\u540e\u80ba\u6ce1\u6db2\u4f53\u7684\u6e05\u9664\u3002KGF\u9884\u5148\u5904\u7406\u5927\u9f20\uff0c\u5bf9\u76d0\u9178\u9020\u6210\u7684\u80ba\u635f\u4f24\u6709\u4fdd\u62a4\u4f5c\u7528\u3002KGF\u80fd\u4fc3\u8fdb\u80ba\u6ce1\u4e0a\u76aeII\u578b\u7ec6\u80de\u589e\u6b96\uff0c\u5728\u6025\u6027\u80ba\u635f\u4f24\u540e\u7684\u80ba\u6ce1\u635f\u4f24\u4fee\u590d\u4e2d\u5177\u6709\u91cd\u8981\u4f5c\u7528\uff0c\u662f\u4e34\u5e8a\u6f5c\u5728\u7684\u9884\u9632\u53ca\u6cbb\u7597\u80ba\u6c34\u80bf\u7684\u836f\u7269\u3002<\/p>\n<p>KGF\u4e0e\u6d88\u5316\u9053\u635f\u4f24\uff1aKGF\u3001KGFR\u5728\u6574\u4e2a\u80a0\u80c3\u7cfb\u7edf\u5747\u6709\u8868\u8fbe\uff0c\u80fd\u523a\u6fc0\u80a0\u80c3\u7cfb\u7edf\u4e0a\u76ae\u7ec6\u80de\u589e\u6b96\u5206\u5316\uff0c\u964d\u4f4e\u80c3\u9178\u5206\u6ccc\uff0c\u5177\u6709\u6cbb\u7597\u80a0\u80c3\u6e83\u75a1\u7684\u529f\u80fd\u3002\u52a8\u7269\u6a21\u578b\u663e\u793a\uff0c\u653e\u7597\u3001\u5316\u7597\u6cbb\u7597\u764c\u75c7\u65f6\u9884\u5148\u7528KGF\u5904\u7406\u8fd8\u80fd\u8d77\u5230\u4fdd\u62a4\u80a0\u80c3\u7684\u529f\u80fd\u3002<\/p>\n<p>KGF\u4e0e\u89d2\u819c\u635f\u4f24\u4fee\u590d\uff1a\u89d2\u819c\u635f\u4f24\u4fee\u590d\u8fc7\u7a0b\u4e2d\u6d89\u53ca\u8bb8\u591a\u751f\u957f\u56e0\u5b50\uff0c\u5176\u4e2d\u5c31\u5305\u62ecKGF\u3002\u5728\u6d3b\u4f53\u6761\u4ef6\u4e0b\uff0cKGF\u53ef\u660e\u663e\u52a0\u5feb\u89d2\u819c\u4e0a\u76ae\u635f\u4f24\u6062\u590d\u7684\u901f\u5ea6\uff0c\u7f29\u77ed\u4e86\u89d2\u819c\u4e0a\u76ae\u4fee\u590d\u65f6\u95f4\uff0c\u53ef\u7528\u4e8e\u4e34\u5e8a\u89d2\u819c\u75be\u75c5\u7684\u6cbb\u7597\u3002<\/p>\n<p>KGF\u4e0e\u764c\u75c7\uff1a\u80bf\u7624\u7684\u53d1\u751f\u4e2d\u4e0a\u76ae\u7ec6\u80de\u660e\u663e\u589e\u591a\uff0c\u53ef\u80fd\u4e0eKGF\u6709\u5173\u3002\u80f0\u817a\u764c\u3001\u524d\u5217\u817a\u764c\u7b49\u764c\u75c7\u4e2dKGF\u8868\u8fbe\u663e\u8457\u589e\u52a0\u3002KGF\u4e0eKGFR\u7ed3\u5408\u8fd8\u80fd\u4fc3\u8fdb\u5375\u5de2\u764c\u4e0a\u76ae\u7ec6\u80de\u7684\u589e\u6b96\u53ca\u8f6c\u79fb\uff0c\u5728\u5375\u5de2\u764c\u7684\u53d1\u751f\u8fc7\u7a0b\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\uff0cKGF\u5728\u4e73\u817a\u764c\u7684\u53d1\u751f\u53d1\u5c55\u8fc7\u7a0b\u4e2d\u8d77\u7740\u7c7b\u4f3c\u4f5c\u7528\u3002<\/p>\n<p>KGF\u8fd8\u88ab\u62a5\u9053\u53ef\u6cbb\u7597\u80bf\u7624\u653e\u7597\u5316\u7597\u5f15\u8d77\u7684\u53e3\u8154\u9ecf\u819c\u708e\uff1b\u6fc0\u6d3bNrf2\u4fe1\u53f7\u901a\u8def\u5e76\u4fc3\u8fdbHO-1\u3001NOQ-1\u3001GCLC\u7b49\u6297\u6c27\u5316\u86cb\u767d\u8868\u8fbe\uff0c\u5bf9\u7f3a\u8840\u518d\u704c\u6ce8\u5f15\u8d77\u7684\u635f\u4f24\u5177\u6709\u4fdd\u62a4\u529f\u80fd\uff0c\u5bf9\u7d2b\u5916\u7ebf\u5f15\u8d77\u7684\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u7ec6\u80de\u635f\u4f24\u4e5f\u5177\u6709\u4fdd\u62a4\u529f\u80fd\u3002<\/p>\n<h4><span style=\"color: #3366ff;\">KGF\u5e02\u573a\u5e94\u7528<\/span><\/h4>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-40940\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/Palifermin-1.jpg\" alt=\"\" width=\"388\" height=\"282\" srcset=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/Palifermin-1.jpg 388w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/Palifermin-1-200x145.jpg 200w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/Palifermin-1-150x109.jpg 150w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/10\/Palifermin-1-300x218.jpg 300w\" sizes=\"(max-width: 388px) 100vw, 388px\" \/><\/p>\n<p style=\"text-align: center;\"><span style=\"color: #808080;\">Palifermin<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>1\u3001\u00a0 \u836f\u7269\uff1a<\/p>\n<p>Palifermin\u662f\u4eba\u91cd\u7ec4KGF\u56e0\u5b50\uff0c\u662f\u7ecf\u7f8e\u56fdFDA\u8ba4\u8bc1\u7684\u4e0a\u5e02\u836f\u7269\u3002\u80bf\u7624\u60a3\u8005\u7684\u653e\u7597\u5316\u7597\u65f6\u4f1a\u5bfc\u81f4\u80c3\u80a0\u9053\u9ecf\u819c\u708e\u53ca\u53e3\u8154\u9ecf\u819c\u708e\uff0cPalifermin\u9776\u5b9a\u53e3\u8154\u53ca\u80c3\u80a0\u9053\u5185\u819c\u4e0a\u76ae\u7ec6\u80de\u4e0e\u7279\u5b9a\u7684\u4e0a\u76ae\u7ec6\u80de\u8868\u9762\u53d7\u4f53\u76f8\u7ed3\u5408\uff0c\u4ece\u800c\u523a\u6fc0\u4e0a\u76ae\u7ec6\u80de\u7684\u589e\u6b96\u5206\u5316\uff0c\u589e\u5f3a\u7ec6\u80de\u4fdd\u62a4\u4f5c\u7528\u3002<\/p>\n<p>2\u3001\u00a0 \u5316\u5986\u54c1<\/p>\n<p>KGF\u662f\u751f\u7269\u5316\u5986\u54c1\u4e2d\u5e38\u89c1\u7684\u7ec6\u80de\u56e0\u5b50\uff0c\u5e38\u7528\u4e8e\u9ad8\u7ea7\u62a4\u80a4\u5316\u5986\u54c1\u4e2d\uff0c\u5177\u6709\u4ee5\u4e0b\u4f5c\u7528\uff1a<\/p>\n<p>1\uff09\u6297\u76b1\u4f5c\u7528\uff1a\u76f4\u63a5\u4f5c\u7528\u4e8e\u4e0a\u76ae\u7ec6\u80de\uff0c\u6709\u6548\u542f\u52a8\u808c\u80a4\u7ec6\u80de\u7684\u518d\u751f\u548c\u4fee\u590d\u529f\u80fd\uff0c\u629a\u5e73\u8001\u5316\u76b1\u7eb9\uff1b<\/p>\n<p>2\uff09\u4fee\u590d\u4f5c\u7528\uff1a\u65e5\u5149\u6652\u4f24\u3001\u624b\u672f\u540e\u7684\u521b\u9762\uff08\u5982\u7eb9\u7709\u3001\u7eb9\u773c\u7ebf\uff0c\u7eb9\u5507\uff0c\u6f02\u5507\u7b49\uff09\u3001\u8870\u8001\u76ae\u80a4\u3001\u795b\u6591\u540e\u3001\u6697\u75ae\u6cbb\u7597\u53ca\u5176\u521b\u9762\u7b49\u5177\u6709\u5168\u65b9\u4f4d\u7684\u4fee\u590d\u4f5c\u7528\uff1b<\/p>\n<p>3\uff09\u4fdd\u6e7f\u4f5c\u7528\uff1a\u5feb\u901f\u6062\u590d\u89d2\u8d28\u5c42\u4fdd\u6c34\u80fd\u529b\uff0c\u51cf\u7f13\u808c\u80a4\u5185\u6c34\u5206\u5411\u4f53\u5916\u7684\u6563\u5931\u901f\u5ea6\uff0c\u4fee\u590d\u76ae\u80a4\u7684\u5f39\u6027\u4e0e\u5149\u6cfd\uff1b<\/p>\n<p>4\uff09\u6297\u654f\u4f5c\u7528\uff1a\u4fee\u590d\u53d7\u635f\u8868\u76ae\u89d2\u8d28\u5c42\uff0c\u964d\u4f4e\u76ae\u80a4\u654f\u611f\u5ea6\uff0c\u51cf\u5c11\u7ea2\u8840\u4e1d\u7684\u5f62\u6210\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #808080;\">\u53c2\u8003\u6587\u732e<\/span><\/p>\n<p><span style=\"color: #808080;\">1. \u91d1\u840d\uff0c\u674e\u7389\u65b0\uff0c\u9ebb\u5f64\u8f89\uff0c\u4f55\u5b5f\u56ed\u3002\u89d2\u8d28\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u7684\u7814\u7a76\u8fdb\u5c55\u3002\u751f\u7269\u5de5\u7a0b\u8fdb\u5c55\u3010J\u3011\uff0c2001.Vol.21.NO6<\/span><\/p>\n<p><span style=\"color: #808080;\">2. \u5b97\u5baa\u78ca\uff0c\u8521\u666f\u9f99\uff0c\u59dc\u7b03\u94f6\uff0c\u738b\u9b4f\u3002\u89d2\u8d28\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u7684\u7814\u7a76\u8fdb\u5c55\u3002\u4e2d\u56fd\u4fee\u590d\u91cd\u5efa\u5916\u79d1\u6742\u5fd7\u3010J\u3011\uff0c2009\u5e742\u6708\u7b2c2\u5377\u7b2c2\u671f\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u6676\u8bfa\u751f\u7269\u5177\u5907\u6210\u719f\u7684\u86cb\u767d\u8d28\u8868\u8fbe\u548c\u7eaf\u5316\u5e73\u53f0\u3001\u7ec6\u80de\u56e0\u5b50\u751f\u7269\u6d3b\u6027\u68c0\u6d4b\u5e73\u53f0\u548c\u4e25\u683c\u7684\u8d28\u63a7\u4f53\u7cfb\uff0c\u63d0\u4f9b\u9ad8\u7eaf\u5ea6\u9ad8\u6d3b\u6027\u7684KGF\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u8054\u7cfb\u6211\u4eec<\/p>\n<p>\u4e0a\u6d77\u6676\u8bfa\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/p>\n<p>\u7535\u8bdd\uff1a0757-29328131-616<\/p>\n<p>\u624b\u673a\/\u5fae\u4fe1\uff1a13392273325<\/p>\n<p>Q Q\uff1a2775427010<\/p>\n<p>\u4e1a\u52a1\uff1ainfo@gene-optimal.com<\/p>\n<p>\u62db\u8058\uff1ahr@gene-optimal.com<\/p>\n<p>\u5730\u5740\uff1a\u5e7f\u4e1c\u7701\u4f5b\u5c71\u5e02\u4f5b\u5c71\u65b0\u57ce\u5cad\u5357\u5927\u90532\u53f7\u4e2d\u6b27\u4e2d\u5fc3A\u680b<\/p>\n<p>\u5b98\u7f51\uff1awww.gene-optimal.com<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color: #ebf5ff; color: #3366ff; font-size: 10pt;\">\u7248\u6743\u58f0\u660e\uff1a\u672c\u6587\u7cfb\u6676\u8bfa\u751f\u7269\u7f16\u8bd1\u6574\u7406\uff0c\u672a\u7ecf\u6676\u8bfa\u751f\u7269\u6388\u6743\uff0c\u4e0d\u5f97\u8f6c\u8f7d\u548c\u4f7f\u7528\uff0c\u5982\u9700\u83b7\u53d6\u6388\u6743\uff0c\u8bf7\u8054\u7cfb\u6211\u4eec\u3002<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u89d2\u8d28\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08keratinocyte gro&#8230;<\/p>\n","protected":false},"author":1,"featured_media":41089,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"_links":{"self":[{"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/posts\/40937"}],"collection":[{"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/comments?post=40937"}],"version-history":[{"count":2,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/posts\/40937\/revisions"}],"predecessor-version":[{"id":40945,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/posts\/40937\/revisions\/40945"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/media\/41089"}],"wp:attachment":[{"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/media?parent=40937"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/categories?post=40937"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/tags?post=40937"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}