{"id":40980,"date":"2018-11-13T10:27:26","date_gmt":"2018-11-13T02:27:26","guid":{"rendered":"https:\/\/www.gene-optimal.com\/?p=40980"},"modified":"2019-08-16T09:58:49","modified_gmt":"2019-08-16T01:58:49","slug":"note-vegf","status":"publish","type":"post","link":"https:\/\/www.gene-optimal.com\/note-vegf\/","title":{"rendered":"\u7ec6\u80de\u56e0\u5b50\u5c0f\u7b14\u8bb0\u4e4bVEGF"},"content":{"rendered":"<p>\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08Vascular endothelial growth factor\uff0cVEGF\uff09\u53c8\u79f0\u8840\u7ba1\u901a\u900f\u56e0\u5b50(Vascular permeability factor\uff0cVPF)\u6216\u8840\u7ba1\u8c03\u7406\u7d20(vasculotropin)\u3002<\/p>\n<p>1983\u5e74Senger\u5c06\u80bf\u7624\u690d\u5165\u8c5a\u9f20\u7684\u8179\u819c\u8154\u4e2d\uff0c\u89c2\u5bdf\u8179\u6c34\u589e\u52a0\u7684\u60c5\u51b5\uff0c\u63d0\u53d6\u7eaf\u5316\u8179\u6c34\u548c\u80bf\u7624\u7ec4\u7ec7\u53d1\u73b0\u4e86\u4e00\u79cd\u5206\u5b50\u91cf\u4e3a34-42\u5343\u9053\u5c14\u987f\u7684\u86cb\u767d\u8d28\uff0c\u53d1\u73b0\u5b83\u53ef\u4ee5\u8bf1\u5bfc\u8840\u6e05\u86cb\u767d\u7531\u8840\u7ba1\u6e17\u6f0f\u800c\u4e0d\u5f15\u8d77\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u635f\u4f24\uff0c\u79f0\u4e3a\u8840\u7ba1\u901a\u900f\u6027\u56e0\u5b50VPF\uff0c\u4e4b\u540e\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u7279\u5f02\u6027\u4f5c\u7528\u4e8e\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u591a\u529f\u80fd\u7ec6\u80de\u56e0\u5b50\uff0c\u5728\u4f53\u5185\u6709\u8bf1\u5bfc\u8840\u7ba1\u751f\u957f\u3001\u8840\u7ba1\u5f62\u6210\u3001\u5185\u76ae\u7ec6\u80de\u589e\u6b96\u8fc1\u79fb\uff0c\u589e\u52a0\u8840\u7ba1\u901a\u900f\u6027\u7684\u4f5c\u7528\uff0c\u6545\u53c8\u88ab\u79f0\u4e3aVEGF\u3002<\/p>\n<p>VEGF\u5bb6\u65cf\u5305\u62ec7\u4e2a\u6210\u5458\uff0cVEGF-A\u3001B\u3001C\u3001D\u3001E\u3001F\u548cPLGF(Plaeeta Growth Factor\uff0c\u80ce\u76d8\u751f\u957f\u56e0\u5b50)\u3002\u4eba\u4f53\u53ef\u8868\u8fbeVEGF-A\u3001VEGF-B\u3001VEGF-C\u3001VEGF-D\u53caPLGF\uff0cVEGF-E\u7531\u7f8a\u75d8\u75ae\u75c5\u6bd2\u4ea7\u751f\uff0cVEGF-F\u4ece\u86c7\u6bd2\u4e2d\u5206\u79bb\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><span style=\"color: #3366ff;\">VEGF\u5bb6\u65cf\u6210\u5458\u9057\u4f20\u5b66\u4fe1\u606f<\/span><\/h4>\n<p><span style=\"color: #3366ff;\">VEGF-A<\/span><\/p>\n<p>VEGF-A\u53d1\u73b0\u6700\u65e9\uff0c\u5728\u7ec4\u7ec7\u548c\u7ec6\u80de\u4e2d\u542b\u91cf\u6700\u4e30\u5bcc\uff0c\u5728\u8840\u7ba1\u53d1\u751f\u3001\u8840\u7ba1\u751f\u6210\u3001\u539f\u59cb\u5185\u76ae\u7ec6\u80de\u5206\u5316\u8fc7\u7a0b\u4e2d\u8d77\u5230\u5173\u952e\u6027\u4f5c\u7528\uff0c\u6545\u901a\u5e38\u53eb\u505aVEGF\uff0c\u6587\u732e\u4e2d\u5e38\u89c1\u7684VEGF\u4e00\u822c\u6307\u7684\u5c31\u662fVEGF-A\u3002<\/p>\n<p>\u4eba\u7684VEGF\u57fa\u56e0\u4f4d\u4e8e6\u53f7\u67d3\u8272\u4f53\u77ed\u81c21\u533a2\u5e26\uff086p2l\uff09\uff0c\u57fa\u56e0\u5168\u957f28 Kb\uff0c\u7f16\u7801\u57fa\u56e0\u957f14 Kb\uff0c\u75318\u4e2a\u5916\u663e\u5b50\u53ca7\u4e2a\u5185\u542b\u5b50\u6784\u6210\u3002\u7f16\u7801\u4ea7\u7269\u4e3a\u540c\u6e90\u4e8c\u805a\u4f53\u7cd6\u86cb\u767d\uff0c\u7b49\u7535\u70b9\u4e3a8.5\uff0c\u6709\u5f88\u5f3a\u7684\u8010\u70ed\u548c\u8010\u9178\u80fd\u529b\u3002<\/p>\n<p>VEGF\u8f6c\u5f55\u540e\uff0c\u7531\u4e8emRNA\u526a\u63a5\u65b9\u5f0f\u7684\u4e0d\u540c\uff0c \u53ef\u4ee5\u5f62\u6210VEGF -121\u3001VEGF -145\u3001VEGF- 148\u3001VEGF -165\u3001VEGF -183\u3001VEGF -189\u548cVEGF- 206 \u7b4916\u79cd\u5de6\u53f3\u7684VEGF\u53d8\u5f02\u4f53\u3002VEGF\u529f\u80fd\u4e0a\u7684\u5dee\u5f02\u4e3b\u8981\u53d6\u51b3\u4e8e\u4e0e\u809d\u7d20\u7684\u4e0d\u540c\u7ed3\u5408\u529b\uff0cVEGF-121 \u7f3a\u4e4fVEGF\u57fa\u56e0\u5916\u663e\u5b506\u548c7\u7f16\u7801\u7684\u6c28\u57fa\u9178\uff0c\u4e0d\u4f1a\u7ed3\u5408\u5728\u809d\u78f7\u8102\u6216\u8005\u7ec6\u80de\u5916\u57fa\u8d28\u4e0a\uff0c\u9664VEGF -121\u5916\uff0c\u6240\u6709VEGF\u5747\u53ef\u4e0e\u809d\u7d20\u7ed3\u5408\u3002<\/p>\n<p>VEGF-121\u4e0eVEGF -165\u4e3a\u53ef\u6eb6\u6027\u5206\u6ccc\u86cb\u767d\uff0c\u662f\u4e3b\u8981\u6548\u5e94\u5206\u5b50\uff0c\u5747\u4ee5\u65c1\u5206\u6ccc\u5f62\u5f0f\u4ecb\u5bfc\u7279\u5f02\u6027\u5185\u76ae\u7ec6\u80de\u6709\u4e1d\u5206\u88c2\u548c\u589e\u52a0\u8840\u7ba1\u901a\u900f\u6027\u3002\u4f53\u5185VEGF -165\u8868\u8fbe\u6700\u4e30\u5bcc\uff0cVEGF -121\u8840\u7ba1\u751f\u957f\u4e2d\u8d77\u4e3b\u5bfc\u4f5c\u7528\u3002\u5404\u79cdVEGF\u4e9a\u578b\u4e2dVEGF165\u4fbf\u4e8e\u808c\u6ce8\u548c\u9759\u8109\u6ce8\u5c04\uff0c\u4e00\u65b9\u9762\u662f\u56e0\u4e3a\u5177\u6709\u53ef\u6eb6\u6027\uff0c\u53e6\u4e00\u65b9\u9762\u5b83\u53ef\u4e0e\u86cb\u767d\u591a\u7cd6\u7ed3\u5408\uff0c\u4f5c\u7528\u65f6\u95f4\u8f83\u957f\uff0c\u4e14\u8bf1\u5bfc\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u589e\u6b96\u7684\u6d3b\u6027\u6700\u5f3a\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" style=\"border: 1px solid #979899; border-radius: 0px; padding: 10px; box-shadow: #979899 0px 0px 6px;\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/11\/vegf-fig1.png\" \/><span style=\"color: #808080;\">Fig1. VEGFA\u5bb6\u65cf\u540c\u6e90\u6027\u5206\u6790<\/span><\/p>\n<p><span style=\"color: #3366ff;\">VEGF-B<\/span><\/p>\n<p>VEGF-B\u57fa\u56e0\u4f4d\u4e8e11q13\uff0c\u957f\u7ea64Kb\uff0c\u67097\u4e2a\u5916\u663e\u5b50\u3002VEGF-B\u57fa\u56e0\u8f6c\u5f55\u540e\uff0cmRNA\u7f16\u8f91\u65b9\u5f0f\u53ef\u5206\u4e3a\u4e24\u79cd\uff0c\u6700\u7ec8\u751f\u6210VEGFB-167\uff0821KD\uff09\u3001VEGFB-186\uff0832KD\uff09\uff0c\u4e8c\u8005\u4e0eVEGFA-165\u7c7b\u4f3c\uff0c\u90fd\u662f\u4ee5\u4e8c\u786b\u952e\u8fde\u63a5\u7684\u4e8c\u805a\u4f53\u3002VEGFB-186\u6bd4VEGFB-167\u591a\u51fa\u4e86\u4e00\u6bb5\u5728\u5916\u663e\u5b506\u4e2d\u63d2\u5165\u7684\u3001\u7531101\u78b1\u57fa\u5bf9\u6838\u9178\u5e8f\u5217\u7f16\u7801\u7684\u591a\u80bd\u3002\u4e24\u4e2a\u5f02\u6784\u4f53\u5728N\u7aef\u6709\u76f8\u540c\u7684115\u4e2a\u6c28\u57fa\u9178\uff0c\u4f46C\u7aef\u4e0d\u540c\uff0cVEGFB-167\u7684C\u7aef\u4e3a\u78b1\u6027\u5e76\u5bcc\u542b\u534a\u80f1\u6c28\u9178\uff0c\u53ef\u4e0e\u809d\u7d20\u7ed3\u5408\uff1b\u800cVEGFB-186\u7684C\u7aef\u5bcc\u542b\u4e19\u6c28\u9178\u3001\u812f\u6c28\u9178\u3001\u4e1d\u6c28\u9178\u548c\u82cf\u6c28\u9178\uff0c\u4e0d\u4e0e\u809d\u7d20\u7ed3\u5408\u3002\u56e0\u6b64VEGFB-167\u662f\u7ec6\u80de\u76f8\u5173\u7684\u5206\u6ccc\u578b\u86cb\u767d\uff1b\u800cVEGFB-186\u7531\u4e8e\u6ca1\u6709\u9ad8\u5ea6\u78b1\u6027\u7684\u57fa\u56e2\uff0c\u53ef\u4ee5\u4ece\u7ec6\u80de\u81ea\u7531\u5206\u6ccc\uff0c\u5e76\u4e14\u4e0d\u4e0e\u7ec6\u80de\u8868\u9762\u6216\u7ec6\u80de\u5468\u56f4\u7684\u786b\u9178\u4e59\u9170\u809d\u7d20\u86cb\u767d\u591a\u7cd6\u7ed3\u5408\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">VEGF-C<\/span><\/p>\n<p>VEGFC\u57fa\u56e0\u5b9a\u4f4d\u4e8e4q34\uff0c\u53ef\u7f16\u7801\u4e00\u4e2a\u7531419\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\u7684\u524d\u4f53\u86cb\u767d\u8d28\u3002\u8fd9\u4e00\u524d\u4f53\u86cb\u767d\u8d28\u4f9d\u6b21\u67094\u4e2a\u533a\u57df\uff1aN\u7aef\u4fe1\u53f7\u591a\u80bd\u3001N\u7aef\u524d\u591a\u80bd\u3001VEGF\u540c\u6e90\u533a\u548cC\u7aef\u524d\u591a\u80bd\u3002VEGFC\u7684VEGF\u540c\u6e90\u533a\u4e0eVEGFA-165\u670930%\u540c\u6e90\u3002VEGFC\u5728\u8bb8\u591a\u6b63\u5e38\u7ec4\u7ec7\u90fd\u6709\u8868\u8fbe, \u5305\u62ec\u5fc3\u808c\u3001\u9aa8\u9abc\u808c\u3001\u80ba\u3001\u80be\u810f\u3002VEGFC\u662f\u7b2c\u4e00\u4e2a\u88ab\u53d1\u73b0\u7684\u6dcb\u5df4\u7ba1\u751f\u6210\u56e0\u5b50\uff0c\u5b83\u53ef\u4ee5\u8bf1\u5bfc\u6dcb\u5df4\u5185\u76ae\u7ec6\u80de\u589e\u6b96\u3001\u8fc1\u79fb\uff0c\u5e76\u5f62\u6210\u6dcb\u5df4\u7aa6\uff0c\u53ef\u80fd\u4e0e\u80bf\u7624\u7684\u6dcb\u5df4\u8f6c\u79fb\u6709\u5173\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">VEGF-D<\/span><\/p>\n<p>VEGFD\u57fa\u56e0\u4f4d\u4e8eXp22.1\uff0c\u5168\u957f50 Kb\uff0c\u75316\u4e2a\u5185\u542b\u5b50\u548c7\u4e2a\u5916\u663e\u5b50\u7ec4\u6210\u3002VEGFD\u86cb\u767d\u542b\u6709354\u4e2a\u6c28\u57fa\u9178\uff0c\u4e0eVEGFC\u670948%\u540c\u6e90\uff0c\u5728VEGF\u5bb6\u65cf\u4e2d\u4e0eVEGFC\u540c\u6e90\u6027\u6700\u9ad8\u3002VEGFD\u4e0eVEGFC\u529f\u80fd\u76f8\u4f3c\uff0c\u53ef\u80fd\u534f\u540c\u53c2\u4e0e\u8840\u7ba1\u3001\u6dcb\u5df4\u7ba1\u751f\u6210\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">PLGF<\/span><\/p>\n<p>PLGF\uff1a\u57fa\u56e0\u5b9a\u4f4d\u4e8e\u67d3\u8272\u4f532p16-21\uff0c\u6709PLGF-1\u548cPLGF-2\u5f02\u6784\u4f53\uff0c\u76ee\u524d\u7814\u7a76\u8f83\u5c11\uff0c\u53ef\u80fd\u5728\u52a8\u8109\u3001\u4fa7\u52a8\u8109\u751f\u6210\u4e2d\u53d1\u6325\u529f\u80fd\uff0c\u53ef\u80fd\u7528\u4e8e\u95ed\u585e\u6027\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6cbb\u7597\u7b49\u7814\u7a76\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><span style=\"color: #3366ff;\">VEGF\u53d7\u4f53<\/span><\/h4>\n<p>VEGF\u6709\u4e09\u79cd\u8de8\u819c\u53d7\u4f53VEGFR-1\uff08Flt-1\uff09\u3001VEGFR-2\uff08\u5728\u4eba\u4f53\u4e2d\u79f0\u4e3aKDR\uff0c\u5c0f\u9f20\u4e2d\u79f0\u4e3aFlk-1\uff09\u3001VEGFR-3\uff08Flk-4\uff09\u3002\u6240\u6709\u53d7\u4f53\u5728\u7ec6\u80de\u5916\u62e5\u6709\uff17\u4e2a\u7c7b\u4f3c\u514d\u75ab\u7403\u86cb\u767d\u7684\u533a\u57df\uff08Immunoglobulin-like domains\uff09\u4ee5\u53ca\u5728\u7ec6\u80de\u5185\u4e00\u4e2a\u916a\u6c28\u9178\u6fc0\u9176\u533a\u57df\uff0c\u6545\u8ba4\u4e3a\u662f\u5c5e\u4e8e\u916a\u6c28\u9178\u6fc0\u9176\u53d7\u4f53\u5bb6\u65cf\u4e9a\u79d1\u3002<\/p>\n<p>VEGFR-1\u4e3b\u8981\u5728\u9020\u8840\u5e72\u7ec6\u80de\u3001\u5355\u6838\u7ec6\u80de\u3001\u5de8\u566c\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0cVEGFR-2\u4e3b\u8981\u5728\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u8868\u8fbe\uff0c\u80bf\u7624\u7ec6\u80de\u4e5f\u8868\u8fbe\u8fd9\u4e24\u79cd\u53d7\u4f53\u3002VEGFR-3\u4e3b\u8981\u5728\u6dcb\u5df4\u5185\u76ae\u7ec6\u80de\u8868\u8fbe\u3002<\/p>\n<p style=\"text-align: left;\">VEGF\u4e9a\u578b\u5bf9\u4e8e\u4e09\u79cd\u53d7\u4f53\u6709\u4e0d\u540c\u7684\u4eb2\u548c\u529b\uff0cVEGFA\u4e3b\u8981\u7ed3\u5408VEGFR-1\u3001VEGFR-2\u3001NRP1\/NRP2\uff0cVEGFB\u548cPLGF\u53ea\u7ed3\u5408\u5728VEGFR-1\u4e0a\uff0cVEGFC\u548cVEGFD\u53ef\u7ed3\u5408\u5728VEGFR-2\u3001VEGFR-3\u4e0a\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" style=\"border: 1px solid #979899; border-radius: 0px; padding: 10px; box-shadow: #979899 0px 0px 6px;\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/11\/vegf-fig2.png\" \/><span style=\"color: #808080;\">Fig2. VEGF\u5bb6\u65cf\u53ca\u5176\u53d7\u4f53<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">VEGF\u8868\u8fbe\u8c03\u63a7<\/span><\/p>\n<p>VEGF\u57fa\u56e0\u7684\u8868\u8fbe\u53d7\u7f3a\u6c27\u3001\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\u3001\u7c7b\u56fa\u9187\u6fc0\u7d20\u3001\u764c\u57fa\u56e0\u3001\u6291\u764c\u57fa\u56e0\u4ea7\u7269\u53ca\u4e00\u4e9b\u5c0f\u5206\u5b50\u7269\u8d28\u7b49\u56e0\u7d20\u7684\u8c03\u63a7\u3002\u86cb\u767d\u6fc0\u9176C\u3001\u96cc\u6fc0\u7d20\u817a\u82f7\u9178\u73af\u5316\u9176\u6fc0\u6d3b\u5242\u3001\u53cc\u6c27\u6c34\u3001\u7d2b\u5916\u7ebf\u4e5f\u53ef\u8bf1\u5bfc\u4ea7\u751fVEGF\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">\u7ec6\u80de\u56e0\u5b50<\/span><\/p>\n<p>\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1 \u3001\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b2\u3001\u8840\u5c0f\u677f\u6e90\u6027\u751f\u957f\u56e0\u5b50\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u957f\u56e0\u5b50\u3001\u767d\u7ec6\u80de\u4ecb\u7d20-1\u3001\u8868\u76ae\u751f\u957f\u56e0\u5b50\u3001\u524d\u5217\u817a\u7d20E\u7b49\uff0c\u5747\u80fd\u4f7fVEGF\u53ca\u5176\u53d7\u4f53\u8868\u8fbe\u4e0a\u8c03\uff0c\u63d0\u9ad8\u5176\u751f\u7269\u5b66\u6d3b\u6027\u3002\u5b9e\u9a8c\u8bc1\u5b9e\uff0cbFGF\u548cVEGF\u8054\u5408\u4f7f\u7528\uff0c\u4f1a\u660e\u663e\u63d0\u9ad8\u8840\u7ba1\u518d\u751f\u7684\u901f\u5ea6\u53ca\u751f\u6210\u8840\u7ba1\u7684\u76f4\u5f84\uff0c\u540c\u65f6\u5927\u5927\u63d0\u9ad8\u4e86\u7f3a\u8840\u80a2\u4f53\u7684\u4f9b\u8840\u3002TNF-\u03b1\u80fd\u4f7f\u4f53\u5916\u57f9\u517b\u7684\u5185\u76ae\u7ec6\u80de\u53d1\u751f\u8fc1\u79fb\u548c\u7ba1\u72b6\u751f\u957f\uff0c\u4f46\u8f83\u4f4e\u7684\u5242\u91cf\u6709\u660e\u663e\u7684\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u7684\u4f5c\u7528\uff0c\u800c\u9ad8\u5242\u91cf\u65f6\u5219\u8868\u73b0\u4e3a\u6291\u5236\u4f5c\u7528\u3002\u628a\u795e\u7ecf\u80f6\u8d28\u7624\u7ec6\u80de\u548cTNF\u03b1\u4e00\u8d77\u57f9\u517b\u540e\u53d1\u73b0\uff0cVEGF\u548cVEGF\u57fa\u56e0\u542f\u52a8\u5b50SP-1\u533a\u7684RNA\u8868\u8fbe\u589e\u9ad8\uff0c\u5176\u589e\u9ad8\u5e45\u5ea6\u4e3a\u5355\u72ec\u5b75\u5316\u795e\u7ecf\u80f6\u8d28\u7624\u76845\u500d\uff0e\u8bc1\u660eTNF-\u03b1\u7684\u8840\u7ba1\u751f\u6210\u4f5c\u7528\u8fd8\u548c\u6fc0\u6d3bVEGF\u57fa\u56e0\u542f\u52a8\u5b50SP-1\u533a\u6709\u5173\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">\u7f3a\u6c27<\/span><\/p>\n<p>\u7f3a\u6c27\u6761\u4ef6\u4e0b\u673a\u4f53\u7ec4\u7ec7VEGF\u8868\u8fbe\u4e0a\u8c03\uff0cVEGF\u5408\u6210\u589e\u591a\uff0c\u5176\u4f5c\u7528\u673a\u5236\u53ef\u80fd\u4e3a\uff1a<\/p>\n<p>\u2460 \u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50(HIF-1)\u8bf1\u5bfc\u542f\u52a8VEGF\u7684\u8f6c\u5f55\uff0cHIF-1\u53d7\u6c27\u6c14\u548c\u751f\u957f\u56e0\u5b50\u7684\u8c03\u8282\uff0c\u53ef\u4ee5\u6fc0\u6d3b\u6b63\u5e38\u7684\u7f3a\u6c27\u611f\u53d7\u57fa\u56e0\uff0cHIF-1\u53ef\u4ee5\u5728\u6570\u5206\u949f\u5185\u4f7fVEGF\u589e\u52a030\u500d\uff0c\u4ece\u800c\u8c03\u63a7VEGF\u8868\u8fbe \uff1b<\/p>\n<p>\u2461 \u5728\u7f3a\u6c27\u73af\u5883\u4e0b\u57f9\u517b\u7ec6\u80de\uff0c\u7ed3\u679c\u53d1\u73b0\u7ec6\u80de\u5185VEGF\u7684\u8868\u8fbe\u53camRNA\u6c34\u5e73\u660e\u663e\u589e\u9ad8\uff0c\u63d0\u793a\u7f3a\u6c27\u53ef\u5bfc\u81f4VEGF\u7684\u8868\u8fbe\u53ca\u91ca\u653e\uff0c\u5e76\u4e14\u662f\u4fc3\u8840\u7ba1\u751f\u6210\u7684\u56e0\u7d20\u4e4b\u4e00\uff1b<\/p>\n<p>\u2462 \u7f3a\u6c27\u4f7f\u5f97\u4e00\u79cd\u6838\u5185\u6838\u7cd6\u86cb\u767d\u4e0eVEGF mRNA\u975e\u7ffb\u8bd1\u533a\u7684\u5bcc\u542bAu\u5143\u4ef6\u5f62\u6210RNA-\u86cb\u767d\u590d\u5408\u7269\uff0c\u53ef\u663e\u8457\u5ef6\u957fVEGF mRNA\u5728\u4f53\u5185\u7684\u534a\u8870\u671f\uff0c\u4ece\u800c\u95f4\u63a5\u63d0\u9ad8VEGF\u7684\u751f\u7406\u6d3b\u6027\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">\u8840\u5c0f\u677f<\/span><\/p>\n<p>\u8840\u5c0f\u677f\u5728VEGF\u7684\u4ea7\u751f\u53ca\u8c03\u8282\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u3002\u5c06\u4eba\u8840\u5c0f\u677f\u548c\u51dd\u8840\u9176\u5728\u4f53\u5916\u5b75\u5316\uff0c\u53d1\u73b0\u6709\u5927\u91cfVEGF\u4ea7\u751f\u3002\u6d3b\u5316\u7684\u8840\u5c0f\u677f\u80fd\u91ca\u653eVEGF\uff0c\u8fd9\u5bf9\u521b\u4f24\u6108\u5408\u53ca\u5176\u4ed6\u75c5\u7406\u6761\u4ef6\u4e0b\u7684\u8840\u7ba1\u5f62\u6210\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u7814\u7a76\u8ba4\u4e3a\uff0c\u8840\u5c0f\u677f\u548c\u635f\u4f24\u7684\u8840\u7ba1\u58c1\u63a5\u89e6\u53ef\u6fc0\u53d1\u51dd\u8840\u673a\u5236\uff0c\u5bfc\u81f4VEGF\u91ca\u653e\u3002\u53e6\u5916\uff0cSalgado\u7b49\u5728\u5bf9\u6076\u6027\u80bf\u7624\u7684\u8840\u6db2\u6807\u672c\u68c0\u6d4b\u65f6\u53d1\u73b0\u3002VEGF\u6d53\u5ea6\u662f\u6b63\u5e38\u76843.2\u500d\u3002\u8fd9\u4e00\u7ed3\u679c\u652f\u6301\u8840\u5c0f\u677f\u5177\u5907\u50a8\u5b58\u6709\u751f\u7269\u6d3b\u6027\u7684VEGF\u7684\u4f5c\u7528\u3002<\/p>\n<p>\u4e00\u4e9b\u539f\u764c\u57fa\u56e0\u548c\u6291\u764c\u57fa\u56e0\u7684\u8868\u8fbe\u4ea7\u7269\uff0c \u4ee5\u53ca\u7c7b\u56fa\u9187\u6fc0\u7d20\u3001\u4ea4\u611f\u795e\u7ecf\u4e5f\u53ef\u4ee5\u8c03\u63a7VEGF\u7684\u8868\u8fbe\u3002\u5982\u4fc3\u7532\u72b6\u817a\u6fc0\u7d20\u53ef\u901a\u8fc7\u65c1\u5206\u6ccc\u673a\u5236\u4fc3\u8fdb\u7532\u72b6\u817a\u7ec6\u80de\u5408\u6210\u3001\u5206\u6cccVEGF\uff1b\u91ce\u751f\u578bp53\u57fa\u56e0\u901a\u8fc7\u4e0e\u8f6c\u5f55\u56e0\u5b50SP-1\u7ed3\u5408\u3002\u53ef\u4e0b\u8c03\u5185\u6e90\u6027VEGF mRNA\uff0c\u5e76\u6291\u5236VEGF\u542f\u52a8\u5b50\u6d3b\u6027\uff0c\u800c\u91cd\u7ec4p53\u57fa\u56e0\u65e0\u6b64\u4f5c\u7528\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><span style=\"color: #3366ff;\">VEGF\u529f\u80fd<\/span><\/h4>\n<p><span style=\"color: #3366ff;\">1\u3001\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u4f5c\u7528<\/span><\/p>\n<p>VEGF\u6700\u4e3b\u8981\u7684\u751f\u7269\u5b66\u4f5c\u7528\u662f\u53ef\u4ee5\u4fc3\u8fdb\u52a8\u8109\u3001\u9759\u8109\u4ee5\u53ca\u6dcb\u5df4\u7ba1\u6765\u6e90\u7684\u5185\u76ae\u7ec6\u80de\u7684\u751f\u957f\u3002\u81ea\u8eab\u5185\u6e90\u6027\u7684VEGF\u662f\u673a\u4f53\u7ec4\u7ec7\u635f\u4f24\u6062\u590d\u91cd\u8981\u7684\u8840\u7ba1\u751f\u957f\u56e0\u5b50\uff0cWagatsuma\u901a\u8fc7\u52a8\u7269\u5b9e\u9a8c\u8bc1\u5b9e\uff0c\u808c\u8089\u635f\u4f24\u540e\u65e9\u671fVEGF\u53ca\u5176\u53d7\u4f53\u7684mRNA\u8868\u8fbe\u660e\u663e\u589e\u9ad8\u4e0e\u635f\u4f24\u65e9\u671f\u7684\u8840\u7ba1\u5316\u7a0b\u5ea6\u5bc6\u5207\u76f8\u5173\uff0c\u4ece\u800c\u4e5f\u95f4\u63a5\u8bf4\u660e\u4e86VEGF\u7684\u91cd\u8981\u7684\u8840\u7ba1\u5316\u4f5c\u7528\u3002<\/p>\n<p>\u6cbb\u7597\u6027\u8840\u7ba1\u751f\u957f\u7d20\u662f\u6cbb\u7597\u7f3a\u8840\u6027\u8840\u7ba1\u75be\u75c5\u7684\u4e00\u4e2a\u65b0\u6982\u5ff5\uff0c\u5b83\u5305\u62ec\u8bf1\u5bfc\u8840\u7ba1\u53d1\u751f\u3001\u5c0f\u52a8\u8109\u751f\u6210\u53ca\u6dcb\u5df4\u7ba1\u751f\u6210 \u3002\u5728\u8840\u7ba1\u751f\u957f\u4e2d\uff0cVEGF\u8c03\u8282\u5185\u76ae\u7ec6\u80de\u80de\u5916\u57fa\u8d28\u6eb6\u89e3\u3001\u5185\u76ae\u7ec6\u80de\u8fc1\u79fb\u3001\u589e\u751f\u548c\u7ba1\u8154\u5f62\u6210\u3002\u5176\u8fc7\u7a0b\u4e3b\u8981\u5305\u62ec\u4ee5\u4e0b\u6b65\u9aa4\uff1a<\/p>\n<p>\u2460 \u8840\u6d46\u7684\u5916\u6e17\uff0c\u65b0\u751f\u8840\u7ba1\u5916\u57fa\u8d28\u7684\u6784\u7b51\uff1b<\/p>\n<p>\u2461 \u65b0\u751f\u8840\u7ba1\u82bd\u96cf\u5f62\u7684\u5f62\u6210\uff1b<\/p>\n<p>\u2462 \u8840\u7ba1\u82bd\u7684\u53d1\u80b2\u548c\u6269\u5c55\uff1b<\/p>\n<p>\u2463 \u65b0\u751f\u8840\u7ba1\u7684\u6210\u719f\u548c\u6539\u5efa\u3002<\/p>\n<p>VEGF\u901a\u8fc7\u589e\u52a0\u8840\u7ba1\u901a\u900f\u6027\uff0c\u4f7f\u8840\u7ba1\u5185\u7ea4\u7ef4\u86cb\u767d\u539f\u7b49\u8840\u6d46\u86cb\u767d\u5916\u6e17\uff0c\u7ea4\u7ef4\u86cb\u767d\u539f\u4e0e\u8840\u7ba1\u5916\u6e17\u7ea4\u7ef4\u8fde\u63a5\u86cb\u767d\u7b49\u591a\u79cd\u6210\u5206\u51dd\u7ed3\u5f62\u6210\u4ea4\u53c9\u7684\u7ea4\u7ef4\u86cb\u767d\u51dd\u80f6\u4f53\uff0c\u4e3a\u5185\u76ae\u7ec6\u80de\u3001\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8fc1\u79fb\u63d0\u4f9b\u4e00\u4e2a\u7ea4\u7ef4\u7f51\u7edc\uff0c\u6709\u5229\u4e8e\u8840\u7ba1\u751f\u6210\u3002<\/p>\n<p>VEGF\u5728\u591a\u79cd\u5728\u4f53\u6a21\u578b\u4e2d\u7684\u4fc3\u8840\u7ba1\u751f\u6210\u4f5c\u7528\u5df2\u7ecf\u88ab\u591a\u4e2a\u5b9e\u9a8c\u6240\u8bc1\u5b9e\u3002\u6b64\u5916\uff0c\u8fd8\u6709\u8bb8\u591a\u7684\u4f53\u5916\u548c\u5728\u4f53\u5b9e\u9a8c\u8868\u660e\uff0cVEGF\u662f\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u751f\u5b58\u56e0\u5b50\uff0cMaharaj\u7b49\u8ba4\u4e3a\u4f4e\u6c34\u5e73\u751f\u7406\u91cf\u7684VEGF-A\u662f\u7ef4\u6301\u8840\u7ba1\u7a33\u5b9a\u6240\u5fc5\u9700\u7684\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">2\u3001\u63d0\u9ad8\u8840\u7ba1\u901a\u900f\u6027<\/span><\/p>\n<p>VEGF\u589e\u52a0\u6bdb\u7ec6\u8840\u7ba1\u540e\u9759\u8109\u548c\u5c0f\u9759\u8109\u7684\u901a\u900f\u6027\uff0c\u4e3b\u8981\u4f5c\u7528\u4e8e\u6bdb\u7ec6\u8840\u7ba1\u540e\u9759\u8109\uff0c\u5728\u51e0\u5206\u949f\u5185\u5373\u53ef\u589e\u52a0\u8840\u7ba1\u5bf9\u8840\u6d46\u86cb\u767d\u7684\u901a\u900f\u6027\uff0c\u5728\u5df2\u77e5\u7684\u5fae\u8840\u7ba1\u901a\u900f\u6027\u8bf1\u5bfc\u7269\u4e2d\u4f5c\u7528\u6700\u5f3a\uff0c\u6548\u5e94\u662f\u7ec4\u7ec7\u80fa\u76845\u4e07\u500d\u3002<\/p>\n<p>\u901a\u8fc7\u8d85\u5fae\u514d\u75ab\u7ec4\u5316\u5b9a\u4f4d\u540e\u53d1\u73b0\uff0cVEGF\u7ed3\u5408\u5728\u5fae\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u7ba1\u8154\u5916\u4fa7\u9762\u548c\u4e00\u79cd\u88ab\u79f0\u4e3a\u56ca-\u6ce1\u5c0f\u4f53(VVO)\u7684\u7ec6\u80de\u5668\u4e0a\u3002VVO\u6a2a\u8de8\u5728\u5185\u76ae\u7ec6\u80de\u7ba1\u8154\u7684\u5185\u4fa7\u9762\u81f3\u5916\u4fa7\u9762\uff0c\u662f\u5185\u76ae\u7ec6\u80de\u7684\u80de\u8d28\u4e2d\u4e00\u4e9b\u56ca\u3001\u6db2\u6ce1\u7ec4\u6210\u7684\u8461\u8404\u7c07\u6837\u7ed3\u6784\u3002\u56ca\u3001\u6db2\u6ce1\u76f4\u63a5\u7531\u4e09\u5c42\u5355\u4f4d\u819c\u76f8\u8fde\uff0c\u6b64\u5916\u8fd8\u6709\u4e00\u4e2a\u7531\u9694\u819c\u7ec4\u6210\u7684\u53ef\u5f00\u95ed\u7684\u5c0f\u5b54\u3002\u5f53\u5b54\u6253\u5f00\u65f6\uff0c\u8840\u6db2\u4e2d\u7684\u5927\u5206\u5b50\u7269\u8d28\u4ece\u76f8\u4e92\u8fde\u63a5\u7684\u56ca\u6ce1\u6db2\u4e2d\u901a\u8fc7\uff0c\u8fdb\u5165\u5468\u56f4\u7684\u7ec4\u7ec7\u95f4\u9699\u4e2d\u3002\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u7684\u57fa\u5e95\u819c\u9762\u548cVVO\u4e2d\u6709\u7ed3\u5408\u7684VEGF\uff0c\u5c40\u90e8\u6ce8\u5c04VEGF\u540e\u53ef\u89c2\u5bdf\u5230VVO\u7684\u529f\u80fd\u589e\u5f3a \u3002<\/p>\n<p>VEGF\u5f15\u8d77\u8840\u7ba1\u901a\u900f\u6027\u589e\u52a0\uff0c\u5bfc\u81f4\u8840\u6d46\u86cb\u767d\u5e7f\u6cdb\u7684\u5916\u6f0f\uff0c\u5176\u4e2d\u5305\u62ec\u51dd\u8840\u56e0\u5b50\u3001\u7ea4\u7ef4\u86cb\u767d\u539f\u3001\u7ea4\u7ef4\u9ecf\u8fde\u86cb\u767d\u3001\u8840\u6d46\u9176\u539f\u7b49\u3002\u8fd9\u4e9b\u86cb\u767d\u76f4\u63a5\u6216\u95f4\u63a5\u6539\u53d8\u4e86\u7ec6\u80de\u5916\u57fa\u8d28\u6210\u5206\uff0c\u4f7f\u5176\u5f62\u6210\u6682\u65f6\u6027\u7684\u65b0\u57fa\u8d28\uff0c\u5141\u8bb8\u5e76\u652f\u6301\u5185\u76ae\u7ec6\u80de\u548c\u6210\u7ea4\u7ef4\u7ec6\u80de\u5185\u5411\u79fb\u52a8\uff0c\u8fc1\u79fb\u5230\u6210\u7ea4\u7ef4\u7ec6\u80de\u5408\u6210\u548c\u5206\u6ccc\u57fa\u8d28\u86cb\u767d\u3001\u86cb\u767d\u805a\u7cd6\uff0c\u5185\u76ae\u7ec6\u80de\u5f62\u6210\u65b0\u7684\u8840\u7ba1\uff0c\u5171\u540c\u6784\u6210\u65b0\u751f\u8089\u82bd\u7ec4\u7ec7\uff0c\u4fee\u590d\u521b\u4f24\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">3\u3001\u5176\u4ed6\u4f5c\u7528<\/span><\/p>\n<p>\u867d\u7136\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u662fVEGF\u53d1\u6325\u4f5c\u7528\u7684\u4e3b\u8981\u9776\u7ec6\u80de\uff0c\u4f46\u662fVEGF\u4e5f\u53ef\u4ee5\u4f5c\u7528\u4e8e\u5176\u4ed6\u4e00\u4e9b\u7ec6\u80de\u5e76\u53d1\u6325\u4fc3\u6709\u4e1d\u5206\u88c2\u4f5c\u7528\uff0c\u4f8b\u5982\uff1a\u80ba\u6ce1\u2161\u578b\u7ec6\u80de\u3001\u6dcb\u5df4\u7ec6\u80de\u3001\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u7ec6\u80de\u3001\u96ea\u65fa\u7ec6\u80de\u7b49\u3002\u6b64\u5916\uff0cVEGF\u5bf9\u9aa8\u9ad3\u6765\u6e90\u7684\u7ec6\u80de\u4e5f\u6709\u4e00\u5b9a\u7684\u4f5c\u7528\uff0c\u5b83\u80fd\u63d0\u9ad8\u5355\u6838\u7ec6\u80de\u7684\u8d8b\u5316\u6027\uff0c\u5e76\u901a\u8fc7\u8bf1\u5bfc\u6746\u72b6\u6838-\u5de8\u566c\u7ec6\u80de\u524d\u4f53\u7ec6\u80de\u7684\u6210\u719f\u4f7f\u514b\u9686\u5f62\u6210\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><span style=\"color: #3366ff;\">VEGF\u76f8\u5173\u75be\u75c5\u53ca\u6cbb\u7597<\/span><\/h4>\n<p><span style=\"color: #3366ff;\">1\u3001 VEGF\u4e0e\u764c\u75c7<\/span><\/p>\n<p>VEGF\u53ca\u5176\u53d7\u4f53\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u9ad8\u6c34\u5e73\u8868\u8fbe\u4e0e\u591a\u79cd\u80bf\u7624\u7684\u9884\u540e\u4e0d\u826f\u6709\u5173, \u8fd9\u4e9b\u80bf\u7624\u5305\u62ec\u661f\u5f62\u7ec6\u80de\u7624\u3001\u80ba\u764c\u3001\u7ed3\u80a0\u764c\u3001\u8180\u80a4\u764c\u3001\u5934\u9888\u9cde\u764c\u3001\u809d\u764c\u7b49\u3002\u80bf\u7624\u8840\u7ba1\u662f\u80bf\u7624\u751f\u957f\u548c\u6d78\u6da6\u3001\u8f6c\u79fb\u7684\u5f62\u6001\u5b66\u57fa\u7840\uff0c\u4e0d\u4ec5\u5411\u80bf\u7624\u7ec4\u7ec7\u63d0\u4f9b\u4e30\u5bcc\u7684\u8425\u517b\uff0c\u4e5f\u5411\u80bf\u7624\u5bbf\u4e3b\u8f93\u51fa\u5927\u91cf\u80bf\u7624\u7ec6\u80de\uff0c\u5bfc\u81f4\u80bf\u7624\u7684\u6269\u6563\u548c\u8f6c\u79fb\u3002\u80bf\u7624\u7ec6\u80de\u7684\u514b\u9686\u6027\u589e\u751f\u9636\u6bb5\u53ca\u7ee7\u4e4b\u800c\u6765\u7684\u8840\u7ba1\u5f62\u6210\u4fc3\u8fdb\u80bf\u7624\u6301\u7eed\u751f\u957f\u7684\u9636\u6bb5\u53d7\u5230\u591a\u79cd\u7ec6\u80de\u56e0\u5b50\u7684\u6b63\u8d1f\u8c03\u8282\uff0c\u5982\u7ea4\u7ef4\u6bcd\u7ec6\u80de\u751f\u957f\u56e0\u5b50( FGF) \u3001\u8f6c\u5316\u751f\u957f\u56e0\u5b50( TGF) \u3001\u8840\u5c0f\u677f\u6e90\u6027\u751f\u957f\u56e0\u5b50( PDGF) \u548c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50( VEGF) \u7b49\uff0c\u5176\u4e2dVEGF \u88ab\u8ba4\u4e3a\u662f\u4fc3\u8fdb\u8840\u7ba1\u5f62\u6210\u7684\u4e3b\u8981\u56e0\u7d20\u3002\u6297\u8840\u7ba1\u5f62\u6210\u662f\u6cbb\u7597\u764c\u75c7\u3001\u80bf\u7624\u7b49\u75be\u75c5\u7684\u7814\u7a76\u65b9\u5411\u3002<\/p>\n<p>VEGF\u6297\u4f53\u836f\u7269\uff1a<\/p>\n<p>\u963f\u74e6\u65af\u6c40\uff08Bevacizumab\uff0cAvastin\uff09\u662f\u91cd\u7ec4\u7684\u4eba\u6e90\u5316\u5355\u514b\u9686\u6297\u4f53\u30022004\u5e742\u670826\u65e5\u83b7\u5f97FDA\u7684\u6279\u51c6\uff0c\u662f\u7f8e\u56fd\u7b2c\u4e00\u4e2a\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\u7684\u6291\u5236\u80bf\u7624\u8840\u7ba1\u751f\u6210\u7684\u836f\u3002\u901a\u8fc7\u6291\u5236\u4eba\u7c7b\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u7684\u751f\u7269\u5b66\u6d3b\u6027\u800c\u8d77\u4f5c\u7528\uff0c\u4e5f\u5c31\u662f\u8bf4\u963f\u74e6\u65af\u6c40\u53ef\u7ed3\u5408VEGF\u5e76\u9632\u6b62\u5176\u4e0e\u5185\u76ae\u7ec6\u80de\u8868\u9762\u7684\u53d7\u4f53\uff08Flt-1\u548cKDR\uff09\u7ed3\u5408\u3002\u5728\u4f53\u5916\u8840\u7ba1\u751f\u6210\u6a21\u578b\u4e0a\uff0cVEGF\u4e0e\u5176\u76f8\u5e94\u7684\u53d7\u4f53\u7ed3\u5408\u53ef\u5bfc\u81f4\u5185\u76ae\u7ec6\u80de\u589e\u6b96\u548c\u65b0\u751f\u8840\u7ba1\u5f62\u6210\u3002\u5728\u63a5\u79cd\u4e86\u7ed3\u80a0\u764c\u7684\u88f8\uff08\u65e0\u80f8\u817a\uff09\u9f20\u6a21\u578b\u4e0a\uff0c\u4f7f\u7528\u963f\u74e6\u65af\u6c40\u53ef\u51cf\u5c11\u5fae\u8840\u7ba1\u751f\u6210\u5e76\u6291\u5236\u8f6c\u79fb\u75c5\u7076\u8fdb\u5c55\u3002Bevacizumab\u7528\u4e8e\u6cbb\u7597\u7ed3\u76f4\u80a0\u764c\uff0c\u4e34\u5e8a\u4e0a\u603b\u4f53\u8010\u53d7\u6027\u597d\uff0c\u4f46\u662f\u6709\u7684\u75c5\u4eba\u51fa\u73b0\u80c3\u80a0\u7a7f\u5b54\u3001\u4f24\u53e3\u6108\u5408\u5e76\u53d1\u75c7\u3001\u8840\u6813\u5e76\u53d1\u75c7\u3001\u9ad8\u8840\u538b\u3001\u51fa\u8840\u3001\u86cb\u767d\u5c3f\u7b49\u526f\u4f5c\u7528\u3002\u963f\u74e6\u65af\u6c40\u52a0\u7d2b\u6749\u9187\u548c\u5361\u94c2\u5316\u7597\u7528\u4e8e\u6cbb\u7597\u975e\u9cde\u72b6\u3001\u975e\u5c0f\u7ec6\u80de\u764cIII\u671f\u4e34\u5e8a\u6548\u679c\u660e\u663e\u3002\u963f\u74e6\u65af\u6c40\u8fd8\u7528\u4e8e\u6cbb\u7597\u80be\u7ec6\u80de\u764c\u3001\u4e73\u817a\u764c\u7b49\uff0c\u8fd8\u5904\u4e8e\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\uff0c\u5e02\u573a\u524d\u666f\u5e7f\u9614\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" style=\"border: 1px solid #979899; border-radius: 0px; padding: 0px; box-shadow: #979899 0px 0px 6px;\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/11\/vegf-fig3.png.jpg\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>VEGFR\u6291\u5236\u5242\uff1a<\/p>\n<p>\u8212\u5c3c\u66ff\u5c3c(Sunitinib,Sutent)\u662f\u4e00\u7c7b\u80fd\u591f\u9009\u62e9\u6027\u5730\u9776\u5411\u9488\u5bf9\u591a\u79cd\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u7684\u65b0\u578b\u836f\u7269\u4e2d\u7684\u7b2c\u4e00\u4e2a\u836f\u7269\u3002\u5b83\u901a\u8fc7\u963b\u65ad\u80bf\u7624\u751f\u957f\u6240\u9700\u7684\u8840\u6db2\u548c\u8425\u517b\u7269\u8d28\u4f9b\u7ed9\u548c\u76f4\u63a5\u653b\u51fb\u80bf\u7624\u7ec6\u80de\u8fd9\u4e24\u79cd\u4f5c\u7528\u673a\u5236\u6765\u5bf9\u6297\u80bf\u7624,\u56e0\u6b64\u5176\u4e34\u5e8a\u4f18\u52bf\u662f\u663e\u800c\u6613\u89c1\u7684\u3002\u5b83\u53ef\u80fd\u4ee3\u8868\u4e86\u65b0\u4e00\u8f6e\u9776\u5411\u7597\u6cd5\u7684\u95ee\u4e16\u3002\u745e\u683c\u975e\u5c3c\u7247\uff08Regorafenib\uff09\u3001\u7d22\u62c9\u975e\u5c3c\uff08Sorafenib\uff09\u3001\u963f\u897f\u66ff\u5c3c\uff08Axitinib\uff09\u3001\u82f9\u679c\u9178\u8212\u5c3c\u66ff\u5c3c\uff08Sunitinib malate\uff09\u90fd\u662fVEGFR\u6291\u5236\u5242\uff0c\u6291\u5236VEGF\u4e0eVEGFR\u7684\u7ed3\u5408\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">2\u3001 VEGF\u4e0e\u7f3a\u8840\u6027\u75be\u75c5<\/span><\/p>\n<p>VEGF\u4e0e\u5fc3\u808c\u7f3a\u8840\u635f\u4f24\uff1a<\/p>\n<p>\u6709\u7814\u7a76\u8005\u9009\u53d6\u6709\u5fc3\u7ede\u75db\u75c7\u72b6\u3001\u51a0\u72b6\u52a8\u8109\u9020\u5f71\u8bc1\u5b9e\uff0c\u5e38\u89c4\u6cbb\u7597\u65e0\u6548\u7684\u7537\u6027\u60a3\u8005\uff0c\u5c06phVEGF165\u76f4\u63a5\u5fc3\u808c\u5185\u6ce8\u5c04\uff0c\u7ed3\u679c\u5168\u90e8\u60a3\u8005\u7684\u5fc3\u7ede\u75db\u75c7\u72b6\u90fd\u6709\u7f13\u89e3\uff0c\u5fc3\u808c\u7f3a\u8840\u5f97\u5230\u6539\u5584\u3002<\/p>\n<p>\u7ec4\u7ec7\u5728\u7f3a\u8840\u3001\u7f3a\u6c27\u523a\u6fc0\u4e0bVEGF\u8868\u8fbe\u589e\u52a0\uff0c\u4fc3\u8fdb\u8840\u7ba1\u589e\u751f\uff0c\u4f46\u5185\u6e90\u6027VEGF\u8868\u8fbe\u7684\u589e\u52a0\u4e0d\u8db3\u4ee5\u5c3d\u5feb\u5efa\u7acb\u4fa7\u652f\u5faa\u73af\uff0c\u7ed9\u4e88\u5916\u6e90\u6027VEGF\u65f6\uff0c\u65b0\u751f\u8840\u7ba1\u589e\u52a0\u660e\u663e\uff0c\u6539\u5584\u4fa7\u652f\u5faa\u73af\u8840\u6d41\u548c\u5185\u76ae\u7ec6\u80de\u529f\u80fd\u3002<\/p>\n<p>\u5229\u7528\u7ed3\u624e\u51a0\u8109\u5de6\u524d\u964d\u652f\u6240\u81f4\u7684\u6025\u6027\u5fc3\u808c\u7f3a\u8840\u52a8\u7269\u6a21\u578b\u7814\u7a76\u53d1\u73b0\uff0c\u7ed9\u4e88VEGF\u53ef\u4f7f\u6897\u6b7b\u5fc3\u808c\u5468\u56f4\u65b0\u751f\u8840\u7ba1\u7684\u6570\u91cf\u660e\u663e\u589e\u591a\u3002\u7ed9\u4e88Terplex DNA\u4ecb\u5bfc\u8f6c\u8f7dVEGF\u8d28\u7c92\u4f7f\u5fc3\u5ba4\u8212\u5f20\u538b\u3001\u5fc3\u5ba4\u6536\u7f29\u533a\u548c\u8212\u5f20\u533a\u9762\u79ef\u660e\u663e\u589e\u52a0\uff0c\u4f7f\u52a8\u7269\u6897\u6b7b\u5fc3\u808c\u5468\u56f4\u8840\u7ba1\u5bc6\u5ea6\u589e\u52a050\uff05 \uff0c\u7f29\u5c0f\u6897\u6b7b\u9762\u79ef\uff0c\u63d0\u793aVEGF\u53c2\u4e0e\u4e86\u4fa7\u652f\u5faa\u73af\u3002VEGF\u4e0ePDGF-AB\u3001Ang-2\uff08PVA\uff09\u534f\u540c\u4f5c\u7528\u53ef\u4f7f\u9ad8\u9f84\u8870\u8001\u7684\u52a8\u7269\u5fc3\u529f\u80fd\u5f97\u5230\u77ac\u65f6\u4fdd\u62a4\uff0c\u4f7f\u5fc3\u808c\u6897\u6b7b\u65f6\u5fc3\u808c\u4e27\u5931\u4e0b\u964d50\uff05\u3002Bcl-2\u662f\u516c\u8ba4\u7684\u51cb\u4ea1\u6291\u5236\u57fa\u56e0\uff0c\u5176\u53ef\u6291\u5236\u591a\u79cd\u56e0\u7d20\u5982\u6c27\u81ea\u7531\u57fa\u548cp53\u8bf1\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\u3002\u6709\u7814\u7a76\u53d1\u73b0Bcl-2\u8fc7\u5ea6\u8868\u8fbe\u53ef\u4ee5\u51cf\u5c11\u7f3a\u8840\/\u518d\u704c\u6ce8\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1\uff0c\u5fc3\u808c\u6ce8\u5c04VEGF165\u5728\u51cf\u5c11\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1\u7684\u540c\u65f6\uff0c\u8fd8\u6291\u5236p53\u3001Fas\u3001Bax\u86cb\u767d\u7684\u8868\u8fbe\u548c\u589e\u52a0Bcl-2\u8868\u8fbe\uff0c\u51cf\u5c11\u5fc3\u808c\u6897\u6b7b\u8fc7\u7a0b\u4e2d\u5fc3\u808c\u7ec6\u80de\u51cb\u4ea1\u7684\u6570\u91cf\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>VEGF\u4e0e\u4e0b\u80a2\u7f3a\u8840\u6027\u75be\u75c5\uff1a<\/p>\n<p>\u6709\u7814\u7a76\u5c06VEGF165\u52a0\u5165\u805a\u4e19\u4ea4\u916f\u548c\u805a\u4e59\u4ea4\u916f(\u6bd4\u4f8b85\uff1a15)\u5236\u6210\u7684\u53ef\u964d\u89e3\u590d\u5408\u6750\u6599\u4e2d\uff0c\u7f6e\u5165\u540e\u4e0b\u80a2\u7f3a\u8840\u5c0f\u9f20\u4f53\u5185\u6301\u7eed\u7f13\u6162\u91ca\u653e\uff0c\u7ed3\u679c\u6cbb\u7597\u7ec4\u7f13\u91ca\u7684VEGF\u663e\u793a\u4e86\u8f83\u4e3a\u660e\u663e\u7684\u8840\u7ba1\u751f\u6210\u4f5c\u7528\u3002<\/p>\n<p>\u7814\u7a76\u8005\u5c06VEGF\u57fa\u56e0\u6cbb\u7597\u80a2\u4f53\u7f3a\u8840\u7528\u4e8e\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8be5\u8bd5\u9a8c\u5c0f\u7ec4\u7528hVEGF165\u8d28\u7c92DNA\u6d82\u4e8e\u7403\u56ca\u5bfc\u7ba1\u8868\u9762\uff0c\u7ecf\u80a1\u52a8\u8109\u5c06\u8f93\u9001\u5230\u4e00\u4f4d\u6162\u6027\u4e0b\u80a2\u52a8\u8109\u7f3a\u8840\u60a3\u8005\u80a1\u52a8\u8109\u8fdc\u7aef\uff0c\u6269\u5f20\u7403\u56ca\u8f6c\u67d3\u75c5\u53d8\u533a\u8840\u7ba1\u58c1\u7ec6\u80de\uff0c12\u5468\u540e\u60a3\u80a2\u8840\u6d41\u704c\u6ce8\u589e\u52a0\uff0c\u60a3\u8005\u7f3a\u8840\u75c7\u72b6\u6539\u5584\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>VEGF\u4e0e\u89c6\u7f51\u819c\u7f3a\u8840\u6027\u75c5\u53d8\uff1a<\/p>\n<p>VEGF\u662f\u773c\u90e8\u65b0\u751f\u8840\u7ba1\u5f62\u6210\u6700\u91cd\u8981\u7684\u751f\u957f\u56e0\u5b50\uff0c\u5404\u79cd\u4e0e\u8840\u7ba1\u751f\u6210\u76f8\u5173\u7684\u56e0\u7d20\u5747\u662f\u901a\u8fc7\u76f4\u63a5\u6216\u95f4\u63a5\u8bf1\u5bfcVEGF\u53ca\u5176\u53d7\u4f53\u7684\u8868\u8fbe\u6765\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u3002\u65e9\u4ea7\u513f\u96cc\u6fc0\u7d20\u6c34\u5e73\u7a81\u7136\u4e0b\u964d\uff0c\u89c6\u7f51\u819c\u8840\u7ba1\u6b63\u5e38\u53d1\u80b2\u8fc7\u7a0b\u53d7\u5230\u5f71\u54cd\uff0c\u5728\u5438\u4eba\u8fc7\u591a\u6c27\u6216\u5176\u4ed6\u56e0\u7d20\u9020\u6210\u673a\u4f53\u76f8\u5bf9\u7f3a\u6c27\u540e\uff0c\u6613\u81f4\u89c6\u7f51\u819c\u8840\u7ba1\u5f02\u5e38\u589e\u751f\u3002<\/p>\n<p>\u9a6c\u6653\u534e\u7b49\u53d1\u73b0\u751f\u7406\u6d53\u5ea6\u7684\u96cc\u4e8c\u9187\u5bf9VEGF mRNA\u5177\u6709\u53cc\u91cd\u8c03\u63a7\u4f5c\u7528\uff1a\u6b63\u5e38\u6c27\u6761\u4ef6\u4e0b\u4fc3\u8fdbBRECs VEGF\u8868\u8fbe\uff1b\u4f4e\u6c27\u6761\u4ef6\u4e0b\u901a\u8fc7HIF\u4e001\u4ec5\u964d\u4f4eVEGF\u8868\u8fbe\uff0c\u5e76\u5448\u5242\u91cf\u3001\u65f6\u95f4\u4f9d\u8d56\u6027\u3002\u8fd9\u4e3a\u91c7\u7528\u96cc\u6fc0\u7d20\u9884\u9632\u65e9\u4ea7\u513f\u89c6\u7f51\u819c\u75c5\u53d8\u7684\u53d1\u751f\u63d0\u4f9b\u4e86\u7406\u8bba\u4f9d\u636e\u3002\u901a\u8fc7\u5149\u51dd\u89c6\u7f51\u819c\u9759\u8109\u7684\u65b9\u5f0f\u5236\u6210\u89c6\u7f51\u819c\u4e2d\u592e\u9759\u8109\u963b\u585e(CRVO)\u6a21\u578b\uff0c\u6240\u4ea7\u751f\u7684\u89c6\u7f51\u819c\u7f3a\u8840\u60c5\u51b5\u4e0e\u4e34\u5e8a\u7c7b\u4f3c\uff0c\u5176\u53d8\u5316\u4e3b\u8981\u662f\u5c40\u90e8\u7f3a\u6c27\u3002\u7814\u7a76\u53d1\u73b0\u5149\u51dd\u540e\uff0c\u623f\u6c34\u4e2dVEGF\u6c34\u5e73\u5347\u9ad8\uff0c\u867d\u65f6\u95f4\u5ef6\u957f\u53ef\u89c1\u8679\u819c\u65b0\u751f\u8840\u7ba1\uff0c\u5176\u95f4\u623f\u6c34VEGF\u8fbe\u9ad8\u5cf0\uff0c\u6b64\u65f6\u65b0\u751f\u8840\u7ba1\u4e5f\u6700\u4e25\u91cd\uff0c\u623f\u6c34VEGF\u6c34\u5e73\u4e0b\u964d\u540e\uff0c\u65b0\u751f\u8840\u7ba1\u4e5f\u6d88\u9000\u3002\u76ee\u524d\u5176VEGF\u4e0b\u964d\u7684\u673a\u5236\u5c1a\u4e0d\u6e05\u695a\uff0c\u53ef\u80fd\u4e0e\u4fa7\u679d\u5faa\u73af\u7684\u5f62\u6210\u6709\u5173\u3002\u623f\u6c34VEGF\u6c34\u5e73\u548c\u8679\u819c\u65b0\u751f\u8840\u7ba1\u4e25\u91cd\u7a0b\u5ea6\u4e4b\u95f4\u662f\u540c\u6b65\u5448\u6bd4\u4f8b\u5730\u53d8\u5316\u3002VEGF\u8d85\u8fc7\u4e00\u5b9a\u6d53\u5ea6\u6216\u7f3a\u8840\u8fbe\u5230\u4e00\u5b9a\u7a0b\u5ea6\u65f6\u65b9\u53ef\u4ea7\u751f\u65b0\u751f\u8840\u7ba1\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">3\u3001 VEGF\u4e0e\u8001\u5e74\u9ec4\u6591\u75c5\u53d8<\/span><\/p>\n<p>\u8001\u5e74\u9ec4\u6591\u53d8\u6027(AMD)\u4ee5\u89c6\u7f51\u819c\u4e2d\u592e\u90e8\u4f4d\u7684\u53d8\u6027\u4e3a\u7279\u5f81\uff0c\u9020\u6210\u4e25\u91cd\u53ca\u4e0d\u53ef\u9006\u7684\u89c6\u529b\u635f\u4f24\u3002<\/p>\n<p>\u6709\u4e24\u79cd\u5f62\u5f0f\u7684AMD\uff0c\u4e00\u79cd\u662f\u65b0\u751f\u8840\u7ba1\u578b\uff0c\u4e5f\u88ab\u79f0\u4e3a\u6e7f\u6027AMD\uff0c\u7279\u70b9\u662f\u8109\u7edc\u819c\u65b0\u751f\u8840\u7ba1\u5f62\u6210\uff0c\u8840\u7ba1\u901a\u900f\u6027\u5927\u9020\u6210\u8840\u6db2\u7684\u6e17\u6f0f\uff0c\u5f15\u8d77\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u7684\u5265\u79bb\u4ee5\u53ca\u7ea4\u7ef4\u7622\u75d5\u3002\u53e6\u4e00\u79cd\u662f\u65e0\u65b0\u751f\u8840\u7ba1\u5f62\u6210\u7684\u5e72\u6027AMD\u3002\u5c3d\u7ba1\u6e7f\u6027AMD\u53ea\u5360AMD\u75c5\u4eba\u603b\u6570\u768410%\uff0c\u4f46\u5374\u662f\u4e25\u91cd\u89c6\u529b\u4e27\u5931\u7684\u4e3b\u8981\u4eba\u7fa4\u3002<\/p>\n<p>\u76ee\u524d\u5c1a\u65e0\u6e7f\u6027AMD\u7684\u6709\u6548\u6cbb\u7597\u65b9\u6cd5\u3002\u5f53\u65b0\u751f\u8840\u7ba1\u5f62\u6210\u90e8\u4f4d\u5f88\u786e\u5b9a\u800c\u4e14\u4e0d\u7275\u6d89\u5230\u89c6\u7f51\u819c\u4e2d\u592e\u51f9\u65f6\uff0c\u4f7f\u7528\u6fc0\u5149\u5149\u51dd\u56fa\u6cd5\u6bd4\u8f83\u5408\u9002\u3002\u5149\u52a8\u529b\u6cbb\u7597\u4f7f\u7528\u4e86\u4e00\u79cd\u901a\u8fc7\u9759\u8109\u7ed9\u836f\u7684\u5149\u654f\u611f\u836f\u7269Visudyne\uff0c\u7ea2\u8272\u7684\u51b7\u6fc0\u5149\u53ef\u4ee5\u5c06\u836f\u7269\u6fc0\u6d3b\uff0c\u4ea7\u751f\u6d3b\u6027\u6c27\uff0c\u5835\u585e\u65b0\u751f\u8840\u7ba1\u3002\u5149\u52a8\u529b\u7597\u6cd5\u88ab\u6279\u51c6\u7528\u4e8e\u89c6\u7f51\u819c\u4e2d\u592e\u51f9\u4e0b\u6709\u65b0\u751f\u8840\u7ba1\u7684\u75c5\u4f8b\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u8fd1\u51e0\u5e74\u8fd8\u6709\u51e0\u79cd\u65b0\u7684\u6cbb\u7597\u836f\u7269\u5904\u4e8e\u4e34\u5e8a\u8bd5\u9a8c(http:\/\/www.chemdrug.com\/sell\/24\/)\u9636\u6bb5\uff0c\u4ee5\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09\u4f5c\u4e3a\u9776\u70b9\u7684\u836f\u7269\u662f\u5176\u4e2d\u4e00\u5927\u7c7b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>RNA\u836f\u7269\uff1a<\/p>\n<p>Pegaptanib\uff08\u57f9\u52a0\u66ff\u5c3c\u94a0\uff09\u53ef\u4ee5\u6291\u5236VEGF\u7684\u6d3b\u6027\u3002Pegaptanib\u662f\u4e00\u79cd\u79f0\u4e3aRNA aptamers\u7684\u5316\u5408\u7269\u3002RNA aptamers\u662f\u5be1\u805a\u6838\u82f7\u9178\u5e8f\u5217\uff0c\u53ef\u4ee5\u548c\u7279\u5f02\u7684\u86cb\u767d\uff08\u5982VEGF\uff09\u7ed3\u5408\uff0c\u6291\u5236\u86cb\u767d\u7684\u6d3b\u6027\u3002\u5176\u7b5b\u9009\u8fc7\u7a0b\u5982\u4e0b\uff1a\u9996\u5148DNA\u5be1\u805a\u6838\u82f7\u9178\u6587\u5e93\u88ab\u8f6c\u5f55\u6210RNAs\uff0c\u7136\u540eRNAs\u548cVEGF\u8fdb\u884c\u5b75\u80b2\u5e76\u8fdb\u884c\u8fc7\u6ee4\uff0c\u90a3\u4e9b\u4e0d\u4e0e\u86cb\u767d\u7ed3\u5408\u7684\u5e8f\u5217\u88ab\u6ee4\u6389\uff0c\u800c\u548c\u86cb\u767d\u7ed3\u5408\u7684\u5e8f\u5217\u88ab\u7b5b\u9009\u51fa\u6765\u3002\u8fd9\u4e9bRNA\u5e8f\u5217\u518d\u901a\u8fc7PCR\u8fdb\u884c\u6269\u589e\u3002Pegaptanib\u662f28\u4e2a\u6838\u82f7\u9178\u7ec4\u6210\u7684\u201captamer\u201d\uff0c\u4e09\u7ef4\u7ed3\u6784\u4f7f\u5176\u80fd\u4e0e\u7ec6\u80de\u5916\u7684VEGF \u7ed3\u5408\uff0c\u6291\u5236VEGF\u4e0e\u76f8\u5e94\u7684\u53d7\u4f53\u7ed3\u5408\u3002Pegaptanib\u7684\u6838\u7cd6\u9aa8\u67b6\u7ecf\u8fc7\u4e86\u4fee\u9970\uff0c\u53ef\u4ee5\u5bf9\u6297\u5185\u6e90\u6027\u6838\u9178\u5185\u5207\u9176\u548c\u5916\u5207\u9176\u7684\u964d\u89e3\u3002\u4e24\u4e2a20-kDa \u7684\u805a\u4e59\u4e8c\u9187\u7ed3\u5408\u5230\u6838\u82f7\u9178\u5e8f\u5217\u4e0a\u4f7f\u836f\u7269\u7684\u534a\u8870\u671f\u5ef6\u957f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" style=\"border: 1px solid #979899; border-radius: 0px; padding: 0px; box-shadow: #979899 0px 0px 6px;\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/11\/vegf-fig4.gif\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>\u86cb\u767d\u836f\u7269\uff1a<\/p>\n<p>\u5eb7\u67cf\u897f\u666e\u773c\u7528\u6ce8\u5c04\u6db2\uff08Conbercept Ophthalmic Injection\uff09\u662f\u6cbb\u7597\u7528\u751f\u7269\u5236\u54c1\u2160\u7c7b\u65b0\u836f\uff0c\u7cfb\u4e00\u79cdVEGF\u53d7\u4f53\u4e0e\u4eba\u514d\u75ab\u7403\u86cb\u767dFc\u6bb5\u57fa\u56e0\u91cd\u7ec4\u7684\u878d\u5408\u86cb\u767d\uff0c\u8be5\u836f\u7269\u901a\u8fc7\u7ed3\u5408\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50VEGF\uff0c\u7ade\u4e89\u6027\u6291\u5236VEGF\u4e0e\u53d7\u4f53\u7ed3\u5408\u5e76\u963b\u6b62VEGF\u5bb6\u65cf\u53d7\u4f53\u7684\u6fc0\u6d3b\uff0c\u4ece\u800c\u6291\u5236\u5185\u76ae\u7ec6\u80de\u589e\u6b96\u548c\u8840\u7ba1\u65b0\u751f\uff0c\u8fbe\u5230\u6cbb\u7597\u6e7f\u6027\u5e74\u9f84\u76f8\u5173\u6027\u9ec4\u6591\u53d8\u6027\u7684\u76ee\u7684\u3002\u5eb7\u67cf\u897f\u666e\u773c\u7528\u6ce8\u5c04\u6db2\u662f\u6211\u56fd\u9996\u4e2a\u81ea\u4e3b\u7814\u53d1\u7684\u6cbb\u7597\u8be5\u75c5\u7684\u836f\u7269\uff0c\u5bf9\u89e3\u51b3\u6211\u56fd\u4e34\u5e8a\u7528\u836f\u7684\u53ef\u53ca\u6027\u6709\u79ef\u6781\u610f\u4e49\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" style=\"border: 1px solid #979899; border-radius: 0px; padding: 0px; box-shadow: #979899 0px 0px 6px;\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/11\/vegf-fig5.jpg\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>EYLEA(aflibercept)\u00a0\u662f\u4e00\u79cd\u91cd\u7ec4\u878d\u5408\u86cb\u767d\u4ebaVEGF\u53d7\u4f531\u548c2\u7ec6\u80de\u5916\u7ed3\u6784\u533a\u90e8\u5206\u878d\u5408\u81f3\u4ebaIgG1\u7684Fc\u90e8\u5206\u7ec4\u6210\u5236\u5242\u4e3a\u7b49\u6e17\u6eb6\u6db2\u3002<\/p>\n<p>\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50-A(VEGF-A)\u548c\u80ce\u76d8\u751f\u957f\u56e0\u5b50(PlGF)\u662f\u8840\u7ba1\u751f\u6210\u56e0\u5b50VEGF\u5bb6\u65cf\u7684\u6210\u5458\u3002VEGF\u4e0eVEGFR-1\u548cVEGFR-2\u7ed3\u5408\uff0cPlGF\u53ea\u4e0eVEGFR-1\u7ed3\u5408\uff0c\u4fc3\u8fdb\u65b0\u751f\u8840\u7ba1\u5f62\u6210\u548c\u8840\u7ba1\u901a\u900f\u6027\u3002Aflibercept\u4f5c\u7528\u5982\u540c\u53ef\u6eb6\u6027\u8bf1\u9975\u53d7\u4f53\u4e0eVEGF-A\u548cPlGF\u7ed3\u5408\uff0c\u7ade\u4e89\u6027\u6291\u5236 VEGF-A\u3001PlGF\u4e0eVEGF\u53d7\u4f53\u7ed3\u5408\u3002Aflibercept\u53ef\u6cbb\u7597AMD\uff0c\u4f46\u662f\u4f1a\u6709\u773c\u5185\u708e\u3001\u89c6\u7f51\u819c\u8131\u843d\u3001\u773c\u5185\u538b\u589e\u52a0\u3001\u8840\u6813\u6813\u585e\u4e8b\u4ef6\u7b49\u526f\u4f5c\u7528\u3002<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" style=\"border: 1px solid #979899; border-radius: 0px; padding: 0px; box-shadow: #979899 0px 0px 6px;\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/11\/vegf-fig6.jpg\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #3366ff;\">4\u3001VEGF\u5728\u521b\u4f24\u6108\u5408\u4e2d\u7684\u8868\u8fbe<\/span><\/p>\n<p>\u521b\u4f24\u6108\u5408\u7684\u5173\u952e\u5c31\u662f\u8840\u7ba1\u751f\u6210\uff0c\u5df2\u7ecf\u8bc1\u5b9eVEGF\u662f\u6700\u5f3a\u7684\u4fc3\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u6709\u4e1d\u5206\u88c2\u539f\u3002VEGF\u4f5c\u4e3a\u8840\u7ba1\u751f\u6210\u7684\u4e00\u4e2a\u91cd\u8981\u7684\u8c03\u8282\u56e0\u7d20\uff0c\u5728\u521b\u4f24\u6108\u5408\u7814\u7a76\u4e2d\u5360\u636e\u7740\u7279\u6b8a\u7684\u5730\u4f4d\u3002<\/p>\n<p>VEGF\u5728\u6b63\u5e38\u7ec4\u7ec7\u7684\u8868\u8fbe\u4e00\u822c\u8f83\u5fae\u5f31\uff0c\u4f46\u5728\u521b\u4f24\u6108\u5408\u4e2d\u4f1a\u6709\u8f83\u5f3a\u7684\u8868\u8fbe\u3002<\/p>\n<p>\u5bf9\u5154\u8033\u7f3a\u8840\u6a21\u578b\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u7f3a\u8840\u76ae\u80a4\u53ca\u7f3a\u8840\u521b\u9762VEGF mRNA\u8868\u8fbe\u5747\u4e0a\u8c03\uff0c\u4e14\u4ece\u635f\u4f24\u540e\u7b2c1\u5929\u8d77\u76f4\u81f3\u7b2c10\u5929\u3002\u5bf9\u5927\u9f20\u521b\u4f24\u76ae\u80a4\u5185VEGF\u8868\u8fbe\u7684\u514d\u75ab\u7ec4\u5316\u7814\u7a76\u8868\u660e\uff0c\u521b\u4f24\u7ec4\u4e8e\u4f24\u540e12 h VEGF\u8868\u8fbe\u5f00\u59cb\u589e\u5f3a\uff0c\u4ee524\uff5e48 h\u8868\u8fbe\u6700\u5f3a\u300224\uff5e48 h VEGF\u9664\u5728\u4e0a\u76ae\u7ec6\u80de\u8868\u8fbe\u5916\uff0c\u5728\u5de8\u566c\u7ec6\u80de\u53ca\u65b0\u751f\u6bdb\u7ec6\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u5185\u5448\u5f3a\u9633\u6027\u8868\u8fbe\u300248 h\u540e\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u8868\u8fbe\u6e10\u5f31\u3002<\/p>\n<p>\u5bf9\u6025\u6027\u653e\u5c04\u6027\u6e83\u75a1\u7684\u7814\u7a76\u8bc1\u5b9e\u8f90\u5c04\u635f\u4f24\u7684\u76ae\u80a4\u7ec4\u7ec7\u7ec6\u80de\u5408\u6210\u5206\u6cccVEGF\u7684\u529f\u80fd\uff0c\u5728\u6e83\u75a1\u5f62\u6210\u524d\u88ab\u7535\u79bb\u8f90\u5c04\u8f7b\u5ea6\u6fc0\u6d3b\uff0c\u4f46\u5728\u6e83\u75a1\u5f62\u6210\u540e\uff0c\u5728\u8f90\u5c04\u548c\u521b\u9762\u7684\u53cc\u91cd\u523a\u6fc0\u4e0b\uff0c\u660e\u663e\u4f4e\u4e8e\u5355\u7eaf\u521b\u9762\uff0c\u4e0d\u80fd\u5f62\u6210\u5cf0\u503c\uff0c\u662f\u6e83\u75a1\u5f62\u6210\u3001\u53d1\u5c55\u53ca\u96be\u4ee5\u6108\u5408\u7684\u539f\u56e0\u4e4b\u4e00\u3002<\/p>\n<p>\u5e94\u5f53\u6307\u51fa\uff0c\u4ec5\u8003\u8651VEGF\u7684\u4fc3\u8840\u7ba1\u751f\u6210\u4f5c\u7528\u8fd8\u4e0d\u8db3\u4ee5\u5b8c\u5168\u89e3\u91ca\u7f3a\u8840\u521b\u9762\u5e94\u7528\u5916\u6e90\u6027VEGF\u540e\u8089\u82bd\u7ec4\u7ec7\u7684\u5feb\u901f\u751f\u957f\uff0c\u56e0\u4e3abFGF\u4e5f\u6709\u8f83\u660e\u663e\u7684\u4fc3\u8840\u7ba1\u751f\u6210\u4f5c\u7528\uff0c\u4f46\u5728\u7f3a\u8840\u521b\u9762\u7684\u5e94\u7528\u4e2d\u65e0\u660e\u663e\u6548\u679c\u3002VEGF\u8fd8\u80fd\u589e\u52a0\u5fae\u8840\u7ba1\u901a\u900f\u6027\uff0c\u4fc3\u8fdb\u8840\u6d46\u86cb\u767d\u6e17\u51fa\u53ca\u7ec6\u80de\u8fc1\u79fb\u81f3\u635f\u4f24\u533a\u57df\uff0c\u800cbFGF\u5219\u65e0\u6b64\u7279\u6027\u3002\u53e6\u5916\uff0cVEGF\u4e0e\u5185\u76ae\u7ec6\u80de\u7ed3\u5408\u540e\u4f1a\u91ca\u653e\u8bb8\u591a\u5177\u6709\u751f\u7269\u5b66\u6d3b\u6027\u7684\u751f\u957f\u56e0\u5b50\u53ca\u7ec6\u80de\u56e0\u5b50\uff0c \u800cbFGF\u4e0d\u80fd\u3002\u5728\u7f3a\u8840\u521b\u9762\u6108\u5408\u4e2d\uff0cVEGF165\u4f5c\u7528\u8f83VEGF121\u66f4\u4e3a\u7a81\u51fa\u3002VEGF\u8868\u8fbe\u7684\u8c03\u8282\u673a\u5236\u5c1a\u4e0d\u5341\u5206\u6e05\u695a\uff0c\u4f46\u4e00\u4e9b\u8840\u6e05\u6765\u6e90\u548c\u65c1\u5206\u6ccc\u7684\u751f\u957f\u56e0\u5b50\u4e0e\u7ec6\u80de\u56e0\u5b50\uff0c \u5305\u62ecPDGF\u3001EGF\u3001TNF\u3001TGF\u7b49\u90fd\u80fd\u4f7f\u57f9\u517b\u7ec6\u80deVEGF\u8868\u8fbe\u4e0a\u8c033\uff5e20\u500d\uff0c\u800c\u521b\u4f24\u4fee\u590d\u5404\u9636\u6bb5\u5747\u6709\u4e0a\u8ff0\u56e0\u5b50\u7684\u8868\u8fbe\u3002\u5176\u4e2d\uff0cbFGF\u5177\u6709\u76f4\u63a5\u8c03\u8282\u4f5c\u7528\uff0c\u5e76\u4e14\u4e0eVEGF\u534f\u540c\u4f5c\u7528\u660e\u663e\u9633\u3002\u521b\u4f24\u65e9\u671f\u9636\u6bb5\u7684\u5c40\u90e8\u7ec4\u7ec7\u7f3a\u6c27\uff0c\u5bf9\u8c03\u8282\u521b\u9762VEGF\u7684\u8868\u8fbe\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002<\/p>\n<p>&nbsp;<\/p>\n<h4><span style=\"color: #3366ff;\">\u603b\u7ed3<\/span><\/h4>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0cVEGF\u4e3b\u8981\u901a\u8fc7\u4e0eVEGFR\u7ed3\u5408\uff0c\u53d1\u6325\u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\u3001\u63d0\u9ad8\u8840\u7ba1\u901a\u900f\u6027\u7684\u529f\u80fd\uff0c\u53c2\u4e0e\u7ec4\u7ec7\u521b\u4f24\u4fee\u590d\u3001\u764c\u75c7\u53d1\u751f\u3001\u89c6\u7f51\u819c\u9ec4\u6591\u75c5\u53d8\u7b49\u8fc7\u7a0b\uff0c\u53ef\u7528\u4e8e\u6cbb\u7597\u7f3a\u8840\u6027\u75be\u75c5\uff1bVEGF\u6216VEGFR\u6291\u5236\u5242\u53ef\u4ee5\u963b\u6b62VEGF\u4e0eVEGFR\u7684\u6b63\u5e38\u7ed3\u5408\uff0c\u6cbb\u7597\u764c\u75c7\u3001\u89c6\u7f51\u819c\u9ec4\u6591\u75c5\u53d8\u7b49\u75be\u75c5\u3002VEGF\u6297\u4f53\u3001VEGFR-Fc\u7b49\u751f\u7269\u5236\u54c1\u5e02\u573a\u4e0a\u5df2\u6709\u591a\u79cd\u76f8\u5173\u751f\u7269\u5236\u54c1\u836f\u7269\uff0c\u8001\u836f\u65b0\u7528\u7684\u8bb8\u591a\u7814\u7a76\u5904\u4e8e\u4e34\u5e8a\u7814\u7a76\u9636\u6bb5\uff0c\u603b\u4f53\u4e0a\u5e02\u573a\u5bb9\u91cf\u5de8\u5927\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u53c2\u8003\u6587\u732e<\/p>\n<ol>\n<li>\u8521\u6e90\u6e90\u3002\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u7684\u8c03\u63a7\u53ca\u5176\u4f5c\u7528\u7814\u7a76\u8fdb\u5c55\u3002\u7ec4\u7ec7\u5de5\u7a0b\u4e0e\u91cd\u5efa\u5916\u79d1\u6742\u5fd7\uff0c2011\u5e742\u6708\u7b2c7\u5377\u7b2c1\u671f\u3002<\/li>\n<li>\u94b1\u671d\u5357\uff0c\u9602\u534e\u5e86\u3002\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u7684\u7814\u7a76\u8fdb\u5c55\u3002\u4e2d\u56fd\u75c5\u7406\u751f\u7406\u6742\u5fd7\uff0c1999\uff0c15\uff089\uff09\u3002<\/li>\n<li>\u5218\u5c0f\u82b3\uff0c\u8bf8\u5170\u8273\u3002VEGF \u53ca\u5176\u4e0e\u80ba\u764c\u7684\u5173\u7cfb\u3002\u4e2d\u534e\u73b0\u4ee3\u5185\u79d1\u5b66\u6742\u5fd7\uff0c2009\u5e74\u7b2c6\u5377\u7b2c4\u671f\u3002<\/li>\n<li>\u8d75\u5c0f\u5cf0\uff0c\u8463\u6d69\uff0e\u9ec4\u6653\u5e73\uff0c\u8bb8\u745e\u5b89\uff0c\u5201\u52c7\u3002\u4ee5VEGF\/VEGFR\u4e3a\u9776\u70b9\u7684\u809d\u764c\u836f\u7269\u7814\u7a76\u8fdb\u5c55\u3002\u6d77\u5ce1\u836f\u5b66\uff0c2009\u5e74\u7b2c21\u5377\u7b2c7\u671f\u3002<\/li>\n<li>\u9f9a\u6d77\u82f1\uff0c\u674e\u5efa\u5b87\uff0c\u5f20\u4e3d\uff0c\u5d14\u9896\u3002VEGF\u5728\u7f3a\u8840\u6027\u75be\u75c5\u4e2d\u7684\u7814\u7a76\u8fdb\u5c55\u3002\u6b66\u8b66\u533b\u5b66\u9662\u5b66\u62a5\uff0c\u7b2c20\u5377\u7b2c6\u671f2011\u5e746\u6708\u3002<\/li>\n<li>\u90b9\u6587\u840d\uff0c\u5510\u56fd\u5f3a\uff0c\u674e\u5149\u660e\u3002VEGF\u53ca\u5176\u53d7\u4f53\u7684\u751f\u7269\u5b66\u7279\u6027\u3002\u56db\u5ddd\u751f\u7406\u79d1\u5b66\u6742\u5fd7\uff0c2012\uff0c34\uff083\uff09\u3002<\/li>\n<li>Ferrara N\uff0cGerber 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