{"id":41051,"date":"2018-12-10T16:50:23","date_gmt":"2018-12-10T08:50:23","guid":{"rendered":"https:\/\/www.gene-optimal.com\/?p=41051"},"modified":"2019-08-15T17:07:30","modified_gmt":"2019-08-15T09:07:30","slug":"note-egf","status":"publish","type":"post","link":"https:\/\/www.gene-optimal.com\/note-egf\/","title":{"rendered":"\u7ec6\u80de\u56e0\u5b50\u5c0f\u7b14\u8bb0\u4e4bEGF"},"content":{"rendered":"<h4><span style=\"color: #3366ff;\">EGF\u7b80\u4ecb<\/span><\/h4>\n<p>20\u4e16\u7eaa60\u5e74\u4ee3\u521d\uff0cMontalcini \u548cCohen\u6559\u6388\u5728\u7eaf\u5316\u5c0f\u9f20\u988c\u4e0b\u817a\u795e\u7ecf\u751f\u957f\u56e0\u5b50(NGF)\u65f6\u53d1\u73b0\u4e00\u79cd\u53ef\u4fc3\u8fdb\u65b0\u751f\u5c0f\u9f20\u63d0\u65e9\u5f00\u773c\u3001\u957f\u7259\u4e14\u5bf9\u70ed\u7a33\u5b9a\u7684\u591a\u80bd\u7c7b\u7269\u8d28\uff0c\u540e\u7eed\u7814\u7a76\u53d1\u73b0\u5b83\u5177\u6709\u6291\u5236\u80c3\u9178\u5206\u6ccc\u4f5c\u7528\uff0c\u6545\u53c8\u79f0\u201c\u6291\u80c3\u7d20\u201d\u3002\u968f\u540e\u5c06\u201c\u6291\u80c3\u7d20\u201d\u52a0\u5165\u57f9\u517b\u7684\u76ae\u80a4\u8868\u76ae\u65f6\uff0c\u53d1\u73b0\u5b83\u53ef\u76f4\u63a5\u4fc3\u8fdb\u8868\u76ae\u751f\u957f\uff0c\u4e3a\u6b64\u88ab\u5b9a\u540d\u4e3a\u8868\u76ae\u751f\u957f\u56e0\u5b50(Epidermal growth factor\uff0cEGF)\u3002\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50(hEGF)\u4e8e1974\u5e74\u4ece\u4eba\u5c3f\u4e2d\u88ab\u63d0\u7eaf\u51fa\u6765\uff0c\u5176\u753153\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\uff0c\u5206\u5b50\u91cf6045\u9053\u5c14\u987f\uff0c\u5206\u5b50\u5185\u67096\u4e2a\u534a\u80f1\u6c28\u9178\u7ec4\u6210\u7684\u4e8c\u786b\u952e\uff0c\u5f62\u62103\u4e2a\u5206\u5b50\u5185\u73af\u578b\u7ed3\u6784\uff0c\u7ec4\u6210\u751f\u7269\u6d3b\u6027\u6240\u5fc5\u9700\u7684\u53d7\u4f53\u7ed3\u5408\u533a\u57df\u3002<\/p>\n<p>EGF\u65e0\u7cd6\u57fa\u90e8\u4f4d\uff0c\u975e\u5e38\u7a33\u5b9a\uff0c\u8010\u70ed\u8010\u9178\uff0c\u5e7f\u6cdb\u5b58\u5728\u4e8e\u4f53\u6db2\u548c\u591a\u79cd\u817a\u4f53\u4e2d\uff0c\u4e3b\u8981\u7531\u988c\u4e0b\u817a\u3001\u5341\u4e8c\u6307\u80a0\u5408\u6210\uff0c\u5728\u4eba\u4f53\u7684\u7edd\u5927\u591a\u6570\u4f53\u6db2\u4e2d\u5747\u5df2\u53d1\u73b0\uff0c\u5728\u4e73\u6c41\u3001\u5c3f\u6db2\u3001\u7cbe\u6db2\u4e2d\u7684\u542b\u91cf\u7279\u5f02\u6027\u5730\u589e\u9ad8\uff0c\u4f46\u5728\u8840\u6e05\u4e2d\u7684\u6d53\u5ea6\u8f83\u4f4e\u3002<\/p>\n<p>\u4f17\u591a\u7684\u5b9e\u9a8c\u7814\u7a76\u8868\u660e\uff0cEGF\u53ef\u523a\u6fc0\u591a\u79cd\u7ec6\u80de\u7684\u589e\u6b96\uff0c\u4e3b\u8981\u662f\u8868\u76ae\u7ec6\u80de\u3001\u5185\u76ae\u7ec6\u80de\u3002\u7528\u4e8e\u89d2\u819c\u635f\u4f24\u3001\u70e7\u70eb\u4f24\u53ca\u624b\u672f\u7b49\u521b\u9762\u7684\u4fee\u590d\u548c\u6108\u5408\u53d6\u5f97\u4e86\u5f88\u597d\u7684\u7597\u6548\uff0cMontalcini \u548cCohen\u6559\u6388\u56e0\u4e3a\u53d1\u73b0\u8868\u76ae\u751f\u957f\u56e0\u5b50\u5e76\u5206\u6790\u5176\u7ed3\u6784\u548c\u4f5c\u7528\u673a\u7406\uff0c\u83b7\u5f97\u4e861986\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u53ca\u533b\u5b66\u5956\u3002<\/p>\n<h4><span style=\"color: #3366ff;\">\u4ebaEGF\u9057\u4f20\u4fe1\u606f<\/span><\/h4>\n<p>\u4ebaEGF\u57fa\u56e0\u4f4d\u4e8e4\u53f7\u67d3\u8272\u4f53\u957f\u81c22\u533a5\u5e26\uff0c\u5176\u86cb\u767d\u4ea7\u7269\u75311207\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\uff0c\u86cb\u767d\u4ea7\u7269\u8fdb\u4e00\u6b65\u52a0\u5de5\u4e3a\u753153\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\u7684\u6210\u719fEGF\u3002\u6210\u719fEGF\u5206\u5b50\u91cf\u7ea66.3kd\uff0c\u7b49\u7535\u70b94.44\uff0c\u5176\u6c28\u57fa\u9178\u5e8f\u5217\u5982\u4e0b\uff1a<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" style=\"box-shadow: #979899 0px 0px 10px; border: 1px solid #979899; border-radius: 0px;\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/12\/EGF-1.png\" \/><\/p>\n<p style=\"text-align: center;\"><span style=\"color: #595959;\">Fig1. EGF\u86cb\u767d\u6c28\u57fa\u9178\u5e8f\u5217<\/span><\/p>\n<p><span style=\"color: #3366ff;\">\u4ebaEGF\u53d7\u4f53\uff1aEGFR<\/span><\/p>\n<p>\u4ebaEGFR\u6709\u591a\u79cd\u540c\u6e90\u5f02\u6784\u4f53\uff0c\u5176\u4e2da\u578b\u5f02\u6784\u4f53\uff08NCBI Reference Sequence: NP_005219.2\uff09\u4e3a\u7f16\u7801\u5e8f\u5217\u6700\u957f\u7684\u7c7b\u578b\uff0c\u5176\u6210\u719f\u540e\u542b\u67091186\u4e2a\u6c28\u57fa\u9178\uff0c\u5206\u5b50\u91cf\u7ea6132kd\u3002<\/p>\n<p>EGFR\u5728\u4e0a\u76ae\u7ec6\u80de\u3001\u95f4\u5145\u8d28\u7ec6\u80de\u7b49\u8bb8\u591a\u7c7b\u578b\u7ec6\u80de\u4e2d\u8868\u8fbe\uff0c\u662f\u4e00\u79cd\u7cd6\u86cb\u767d\uff0c\u5c5e\u4e8e\u916a\u6c28\u9178\u6fc0\u9176\u578b\u53d7\u4f53\u3002EGFR\u5b9a\u4f4d\u4e8e\u7ec6\u80de\u819c\uff0c\u5206\u4e3a\u5916\u819c\u533a\u3001\u8de8\u819c\u533a\u53ca\u80de\u5185\u533a\uff0cEGFR\u86cb\u767dN\u7aef622\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u4f4d\u4e8e\u5916\u819c\u533a\uff0c\u8de8\u819c\u533a\u4e3a22\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u6784\u6210\u7684\u03b1\u87ba\u65cb\u7ed3\u6784\uff0c\u80de\u5185\u533a\u4e3aEGFR\u86cb\u767dC\u7aef542\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\u7684\u591a\u80bd\u6bb5\uff0c\u8be5\u591a\u80bd\u6bb5\u53ef\u7ec6\u5206\u4e3a\u53cd\u9988\u8870\u51cf\u533a\uff08\u53ef\u88abPKC\u3001Erk\u3001\u5f02\u4e09\u805a\u4f53g\u86cb\u767d\u8bc6\u522b\uff0c\u7ea6\u753150\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\uff09\u3001\u916a\u6c28\u9178\u6fc0\u9176\u533a(SH1\uff0csrc homology 1\uff1b\u7ea6\u7531250\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\uff09\u3001\u7fa7\u7aef\u5c3e\u90e8\u533a\uff08\u7531229\u4e2a\u6c28\u57fa\u9178\u7ec4\u6210\uff0c\u542b\u67095\u4e2a\u81ea\u78f7\u9178\u5316\u7ed3\u6784\u57df\uff09\u3002<\/p>\n<p>EGF\u3001TGF\u03b1\u3001HB-EGF\u3001\u795e\u7ecf\u8c03\u8282\u7d202-\u03b1(NRG2-\u03b1)\u3001\u53cc\u8c03\u8282\u86cb\u767d(Amphiregulin)\u7b49\u80fd\u4e0eEGF\u53d7\u4f53\u7ed3\u5408\u4f7fEGFR\u5f62\u6210\u4e8c\u805a\u4f53\u7ed3\u6784\uff0c\u5f15\u8d77\u81ea\u8eab\u53d1\u751f\u78f7\u9178\u5316\u5e76\u4f7f\u4e0b\u6e38MAPK\u3001Akt\u3001JNK\u7b49\u4fe1\u53f7\u901a\u8def\u76f8\u5173\u86cb\u767d\u78f7\u9178\u5316\uff0c\u4fc3\u8fdb\u7ec6\u80de\u589e\u6b96\u3001\u7ec6\u80de\u8fc1\u79fb\u3001\u7ec6\u80de\u5206\u5316\u3001\u86cb\u767d\u5206\u6ccc\u7b49\uff0c\u5728\u80da\u80ce\u53d1\u80b2\u3001\u5668\u5b98\u5f62\u6210\u3001\u5668\u5b98\u7ef4\u6301\u4fee\u590d\u7b49\u8fc7\u7a0b\u4e2d\u53d1\u6325\u91cd\u8981\u529f\u80fd\uff0cEGFR\u7b49\u86cb\u767d\u916a\u6c28\u9178\u6fc0\u9176\u529f\u80fd\u7f3a\u5931\u6216\u5176\u76f8\u5173\u4fe1\u53f7\u901a\u8def\u4e2d\u5173\u952e\u56e0\u5b50\u7684\u6d3b\u6027\u6216\u7ec6\u80de\u5b9a\u4f4d\u5f02\u5e38\uff0c\u5747\u4f1a\u5f15\u8d77\u80bf\u7624\u3001\u7cd6\u5c3f\u75c5\u3001\u514d\u75ab\u7f3a\u9677\u53ca\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u53d1\u751f\u3002<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" style=\"box-shadow: #979899 0px 0px 10px; border: 1px solid #979899; border-radius: 0px;\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/12\/EGF-2.jpg\" \/><\/p>\n<p style=\"text-align: center;\"><span style=\"color: #595959;\">Fig2. EGF\u4e0eEGFR\u7ed3\u5408\u590d\u5408\u7269\u6676\u4f53\u7ed3\u6784<\/span><\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" style=\"box-shadow: #979899 0px 0px 10px; border: 1px solid #979899; border-radius: 0px;\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/12\/EGF-3.jpg\" \/><\/p>\n<p style=\"text-align: center;\"><span style=\"color: #595959;\">Fig3. EGF\u4fe1\u53f7\u901a\u8def<\/span><\/p>\n<p>&nbsp;<\/p>\n<h4><span style=\"color: #3366ff;\">EGF\u3001EGFR\u4e0e\u75be\u75c5<\/span><\/h4>\n<p><span style=\"color: #3366ff;\">1\u3001EGF\u3001EGFR\u4e0e\u764c\u75c7<\/span><\/p>\n<p>\u4e34\u5e8a\u6570\u636e\u663e\u793aEGF\u3001EGFR\u57fa\u56e0\u4e0e\u764c\u75c7\u7684\u53d1\u751f\u3001\u8f6c\u79fb\u5bc6\u5207\u76f8\u5173\u3002EGF\u5f71\u54cd\u764c\u75c7\u4e3b\u8981\u4e0eEGF\u542f\u52a8\u5b50\u533a\u57fa\u56e0\u591a\u6001\u6027\u6709\u5173\uff0c\u5982Shahbazi\u7b49\u7814\u7a76\u4e86EGF\u542f\u52a8\u5b50\u533a61\u4f4d\u70b9\u7684EGF 61*G\/A \u57fa\u56e0\u591a\u6001\u6027\u6539\u53d8\u4e0e\u5916\u5468\u8840\u7ec6\u80de\u4e2dEGF\u6c34\u5e73\u53ca\u6076\u6027\u9ed1\u8272\u7d20\u7624\u6613\u611f\u6027\u4e4b\u95f4\u7684\u5173\u7cfb\uff0c\u7ed3\u679c\u53d1\u73b0\u8be5\u4f4d\u70b9\u7684\u7a81\u53d8\u4f1a\u964d\u4f4e\u5916\u5468\u8840\u7ec6\u80de\u7684EGF\u6c34\u5e73\uff0c\u5e76\u4e14\u4f1a\u589e\u52a0\u60a3\u6076\u6027\u9ed1\u8272\u7d20\u7624\u7684\u53d1\u75c5\u98ce\u9669\uff08\u5173\u4e8eEGF\u542f\u52a8\u5b50\u533a\u57fa\u56e0\u591a\u6001\u6027\u4e0e\u764c\u75c7\u7684\u5173\u7cfb\uff0c\u76f8\u5173\u7814\u7a76\u5f88\u591a\uff0c\u4f46\u662f\u7ed3\u679c\u4e0d\u540c\u5b58\u5728\u4e89\u8bae\uff0c\u5177\u4f53\u673a\u5236\u6709\u5f85\u9610\u660e\uff09\u3002<\/p>\n<p><em>egfr\u00a0<\/em>\u57fa\u56e0\u7a81\u53d8\u662f\u5bfc\u81f4\u764c\u75c7\u7684\u91cd\u8981\u539f\u56e0\uff0c<em>egfr\u00a0<\/em>\u7684\u7a81\u53d8\u4e3b\u8981\u53d1\u751f\u5728\u80de\u5185TK\u533a\u57df\u7684\u524d\u56db\u4e2a\u5916\u663e\u5b50\u4e0a\uff0818~21\uff09\uff0c\u76ee\u524d\u53d1\u73b0\u7684TK\u533a\u57df\u7a81\u53d8\u670930\u591a\u79cd\uff0c\u4ed6\u4eec\u80fd\u5bfc\u81f4\u4e0d\u4f9d\u8d56\u4e8e\u914d\u4f53\u7684EGFR\u2002TK\u6fc0\u6d3b\uff0c\u79f0\u4e3a\u6fc0\u6d3b\u7a81\u53d8\u3002<\/p>\n<p>\u6fc0\u6d3b\u7a81\u53d8\u6709\u4e09\u79cd\u7c7b\u578b\uff1a\u7f3a\u5931\u7a81\u53d8\u3001\u66ff\u4ee3\u7a81\u53d8\u3001\u590d\u5236\u6216\u63d2\u5165\u7a81\u53d8\uff0c\u5b83\u4eec\u90fd\u53d1\u751f\u5728TK\u533a\u57df\u7684ATP\u7ed3\u5408\u53e3\u888b\u4e0a\u3002<br \/>\n<img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/12\/EGF-tubian.png\" alt=\"\" \/><br \/>\n\u5176\u4e2d\u5916\u663e\u5b5019\u7684\u7f3a\u5931\u7a81\u53d8\uff08del\u2002E746-A750\uff09\u548c\u5916\u663e\u5b5021\u4e0a\u7684\u66ff\u4ee3\u7a81\u53d8\uff08L858R\uff09\u53c8\u53eb\u7ecf\u5178\u7a81\u53d8\u6216\u70ed\u70b9\u7a81\u53d8\uff0c\u7ea6\u5360\u7a81\u53d8\u768490%\u3002<\/p>\n<p style=\"text-align: left;\">\u5e76\u4e0d\u662f\u6240\u6709\u7684\u7a81\u53d8\u90fd\u662f\u6fc0\u6d3b\u7a81\u53d8\uff0c\u5982\u53d1\u751f\u5728\u5916\u663e\u5b5020\u4e0a\u7684\u66ff\u4ee3\u7a81\u53d8T790M\u4e3a\u8010\u836f\u7a81\u53d8\uff0c\u7814\u7a76\u8fd8\u53d1\u73b0\u6709L858Q\u3001\u2002D761Y\u2002\u3001T854A\u7b49\u8010\u836f\u7a81\u53d8\u3002\u5f02\u5e38\u7684EGFR\u6d3b\u5316\u80fd\u591f\u4fc3\u8fdb\u80bf\u7624\u7ec6\u80de\u7684\u589e\u6b96\u3001\u8fc1\u79fb\u3001\u5206\u5316\u3001\u8840\u7ba1\u65b0\u751f\uff0c\u5e76\u4e14\u80fd\u591f\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u51cb\u4ea1\u3002\u5f02\u5e38\u7684EGFR\u6d3b\u5316\u673a\u5236\u5305\u62ec\u53d7\u4f53\u672c\u8eab\u7684\u6269\u589e\u3001\u53d7\u4f53\u914d\u4f53\u7684\u8fc7\u8868\u8fbe\u3001\u6d3b\u5316\u7a81\u53d8\u4ee5\u53ca\u8d1f\u6027\u8c03\u8282\u9014\u5f84\u7684\u7f3a\u4e4f\uff0c\u5176\u4e2d\u4ee5EGFR\u7684\u7a81\u53d8\u6d3b\u5316\u4e3a\u4e3b\u8981\u673a\u5236\u3002\u5404\u9879\u7814\u7a76\u4e5f\u8868\u660eEGFR\u5728\u591a\u79cd\u80bf\u7624\u7ec6\u80de\u4e2d\u5b58\u5728\u7a81\u53d8\u6216\u6269\u589e\u7684\u60c5\u51b5\uff0c\u5df2\u7ecf\u68c0\u6d4b\u5230\u7684\u7a81\u53d8\u6570\u91cf\u6700\u591a\u7684\u662f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3002<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" style=\"box-shadow: #979899 0px 0px 10px; border: 1px solid #979899; border-radius: 0px;\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/12\/EGF-4.png\" \/><br \/>\n<span style=\"color: #595959;\">Fig4. EGFR\u57fa\u56e0\u5e38\u89c1\u7a81\u53d8\u7c7b\u578b<\/span><\/p>\n<p><span style=\"color: #3366ff;\">2\u3001EGF\u3001EGFR\u4e0e\u751f\u6b96<\/span><\/p>\n<p>EGFR\u5728\u80da\u80ce\u53d1\u80b2\u53ca\u5206\u5316\u7b49\u65b9\u9762\u8d77\u7740\u5f88\u91cd\u8981\u7684\u4f5c\u7528\u3002\u6709\u4e9b\u5b66\u8005\u7528\u57fa\u56e0\u7a81\u53d8\u6280\u672f\u4f7fEGFR\u57fa\u56e0\u5931\u6d3b\u540e\u53d1\u73b0\uff0cEGFR\u7f3a\u5931\u7684CF-1\u7cfb\u5c0f\u9f20\u80da\u80ce\u5728\u7740\u5e8a\u524d\u7531\u4e8e\u5185\u7ec6\u80de\u56e2\u7684\u9000\u5316\u800c\u6b7b\u4ea1\uff1b129\uff0fSv\u7cfb\u5c0f\u9f20\u7a81\u53d8\u4f53\u80da\u80ce\u5728\u598a\u5a20\u4e2d\u671f\u7531\u4e8e\u80ce\u76d8\u7f3a\u635f\u800c\u6b7b\u4ea1\uff1bCD-1\u7cfb\u7a81\u53d8\u4f53\u5c0f\u9f20\u53ef\u4ee5\u5b58\u6d3b3\u5468\u4ee5\u4e0a\uff0c\u8868\u73b0\u4e3a\u76ae\u80a4\u3001\u80be\u3001\u8111\u3001\u809d\u3001\u548c\u80c3\u80a0\u9053\u7b49\u5f02\u5e38\u3002\u5728\u5c0f\u9f20\u80da\u80ce\u4e2d\u867d\u65e0EGF\u7684\u8868\u8fbe\uff0c\u4f46\u5728\u540c\u671f\u5b50\u5bab\u4e0a\u76ae\u7ec6\u80de\u7684\u9876\u90e8\u533a\u57df\u8868\u8fbeEGF\uff1b\u5728\u56ca\u80da\u4e2dEGFR\u4e3b\u8981\u5b58\u5728\u4e8e\u6ecb\u517b\u5c42\u4e2d\uff0c\u4f46\u4e5f\u6709\u5173\u4e8e\u5728\u5185\u7ec6\u80de\u56e2\u4e2d\u68c0\u6d4b\u5230EGFR\u5b58\u5728\u7684\u62a5\u9053\u3002\u8fd9\u4e9b\u7ed3\u679c\u8868\u660e\uff0c\u867d\u7136\u8bb8\u591a\u52a8\u7269\u80da\u80ce\u81ea\u8eab\u4e0d\u80fd\u5408\u6210EGF\uff0c\u4f46EGFR\u7684\u5b58\u5728\u53ef\u4ee5\u4f7f\u5916\u6e90\u7684EGF\u6216\u8005\u8f6c\u5316\u751f\u957f\u56e0\u5b50-\u03b1(TGF-\u03b1)\u3001\u809d\u7d20\u7ed3\u5408\u6027EGF\u6837\u751f\u957f\u56e0\u5b50(HB-EGF)\u7b49\u4e0eEGFR\u7ed3\u5408\u800c\u4f5c\u7528\u4e8e\u80da\u80ce\uff0c\u5f71\u54cd\u80da\u80ce\u7684\u65e9\u671f\u53d1\u80b2\u3002<\/p>\n<p>EGF\u5bf9\u7cbe\u5b50\u53d1\u751f\u8fc7\u7a0b\u5177\u6709\u8c03\u8282\u4f5c\u7528\uff0cTsutsumi\u7b49\u5bf9\u96c4\u6027\u5c0f\u9f20\u505a\u553e\u6db2\u817a\u5207\u5f00\u5f15\u6d41\u672f\u540e\u53d1\u73b0\uff0c\u8840\u6d46EGF\u6c34\u5e73\u663e\u8457\u964d\u4f4e\uff0c\u9644\u777e\u4e2d\u7cbe\u5b50\u6570\u51cf\u5c1150\uff05\u4ee5\u4e0a\uff1b\u5982\u679c\u6bcf\u5929\u7ed9\u8fd9\u4e9b\u5c0f\u9f20\u6ce8\u5c04\u4e00\u5b9a\u91cf\u7684EGF\u5219\u53ef\u963b\u6b62\u7cbe\u5b50\u6570\u76ee\u7684\u51cf\u5c11\uff0c\u5e76\u4f7f\u7cbe\u5b50\u6570\u4e0a\u5347\u3002\u901a\u8fc7\u8fdb\u4e00\u6b65\u5b9e\u9a8c\u53d1\u73b0\uff0c\u5207\u9664\u553e\u6db2\u817a\u7684\u5c0f\u9f20\u7cbe\u5b50\u7ec6\u80de\u6570\u6bd4\u672a\u5904\u7406\u7684\u5c0f\u9f20\u5c11\uff0c\u800c\u7cbe\u6bcd\u7ec6\u80de\u6570\u91cf\u6bd4\u6b63\u5e38\u5c0f\u9f20\u660e\u663e\u589e\u52a0\u3002\u7528\u4e00\u5b9a\u91cf\u7684EGF\u5904\u7406\u5207\u9664\u553e\u6db2\u817a\u7684\u5c0f\u9f20\u540e\uff0c\u5404\u7ea7\u751f\u7cbe\u7ec6\u80de\u6570\u91cf\u4e0e\u6b63\u5e38\u5c0f\u9f20\u7684\u5927\u81f4\u76f8\u540c\u3002EGF\u5bf9\u7cbe\u5b50\u53d1\u751f\u7684\u8c03\u8282\u4f5c\u7528\u662f\u901a\u8fc7\u63a7\u5236\u8f6c\u94c1\u86cb\u767d(transferrin)\u7684\u5206\u6ccc\u6765\u5b9e\u73b0\u7684\uff0c\u8f6c\u94c1\u86cb\u767d\u662f\u7531\u4e24\u4e2a\u5728\u7ed3\u6784\u548c\u529f\u80fd\u4e0a\u7c7b\u4f3c\u7684\u7ed3\u6784\u57df\u7ec4\u6210\u7684\uff0c\u5206\u5b50\u91cf\u7ea6\u4e3a80kDa\u7684\u5355\u4e00\u80bd\u94fe\u7cd6\u86cb\u767d\uff0c\u65e2\u662f\u6700\u91cd\u8981\u7684\u94c1\u8f6c\u8fd0\u86cb\u767d\uff0c\u53c8\u662f\u7ec6\u80de\u751f\u957f\u7684\u4e13\u4e00\u6027\u56e0\u5b50\u3002<\/p>\n<p><span style=\"color: #3366ff;\">3\u3001EGF\u4e0e\u6e83\u75a1<\/span><\/p>\n<p>\u6d88\u5316\u6027\u6e83\u75a1(peptic ulcer\uff0cPU)\u6108\u5408\u8fc7\u7a0b\u4e2d\uff0cEGF\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u6297\u6e83\u75a1\u548c\u4fc3\u8fdb\u6e83\u75a1\u6108\u5408\u7684\u5206\u5b50\u8c03\u8282\u56e0\u5b50\uff0c\u5176\u5bf9\u7ec6\u80de\u589e\u6b96\u548c\u5206\u5316\u7684\u8c03\u63a7\u4f5c\u7528\u5df2\u65e5\u76ca\u53d7\u5230\u91cd\u89c6\u3002EGF\u80fd\u523a\u6fc0\u4e0a\u76ae\u7ec6\u80de\u4e2d\u7684mRNA\uff0cDNA\u548c\u86cb\u767d\u8d28\u5408\u6210\uff0c\u4fc3\u4f7f\u7c98\u819c\u4e0a\u76ae\u7684\u589e\u751f\u3002\u6b64\u5916\uff0c\u6d88\u5316\u9053\u5185\u7684EGF\u8fd8\u53ef\u901a\u8fc7\u58c1\u7ec6\u80de\u4e0a\u7684EGF\u53d7\u4f53\u548c\u5176\u4ed6\u901a\u8def\uff0c\u8bf8\u5982\u81ea\u5206\u6ccc\u3001\u65c1\u5206\u6ccc\u548c\u8fd1\u5206\u6ccc\u7b49\u9014\u5f84\u8c03\u8282\u80c3\u9178\u3002\u8fd1\u5e74\u8fd8\u53d1\u73b0EGF\u7684\u4fdd\u62a4\u4f5c\u7528\u90e8\u5206\u662f\u901a\u8fc7ODC\u9176\u6d3b\u6027\u589e\u52a0\u4ecb\u5bfc\u7684\uff0c\u8be5\u9176\u662f\u591a\u80fa\u7c7b\u751f\u7269\u5408\u6210\u7684\u9650\u901f\u9176\u3002\u56e0\u6b64\u5185\u6e90\u6027EGF\u7f3a\u4e4f\uff0c\u53ef\u76f4\u63a5\u964d\u4f4e\u7c98\u819c\u6297\u635f\u5bb3\u56e0\u7d20\u7684\u9632\u5fa1\u80fd\u529b\uff0c\u4fc3\u4f7f\u6e83\u75a1\u7684\u5f62\u6210\u3002\u4e34\u5e8a\u7814\u7a76\u4ea6\u8bc1\u660e\u6d3b\u52a8\u671fPU\u60a3\u8005\u553e\u6db2\u3001\u80c3\u6db2\u53ca\u8840\u6e05EGF\u542b\u91cf\u660e\u663e\u4f4e\u4e8e\u6b63\u5e38\u4eba\uff0c\u800c\u7ecf\u6cbb\u7597\uff0c\u6e83\u75a1\u5f97\u4ee5\u8fc5\u901f\u6108\u5408\u540e\uff0cEGF\u542b\u91cf\u4ea6\u4e0a\u5347\u6216\u6062\u590d\u81f3\u6b63\u5e38\u3002<\/p>\n<p>\u53e3\u8154\u6e83\u75a1(oral ulce\uff0c OU)\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u53e3\u8154\u9ecf\u819c\u75be\u75c5\uff0c\u75c5\u56e0\u590d\u6742\uff0c\u4e00\u822c\u4eba\u7fa4\u7684\u60a3\u75c5\u7387\u53ef\u9ad8\u8fbe25%\u4ee5\u4e0a\u3002\u5176\u4e2d\u4ee5\u590d\u53d1\u6027\u53e3\u8154\u6e83\u75a1\u6700\u4e3a\u5e38\u89c1\uff0c\u75c5\u7a0b\u4e00\u822c\u4e3a7-10\u5929\uff0c\u53d1\u4f5c\u671f\u95f4\u6709\u6bd4\u8f83\u5267\u70c8\u7684\u707c\u75db\uff0c\u4e25\u91cd\u5f71\u54cd\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u3002\u76ee\u524d\u5bf9\u5176\u53d1\u751f\u7684\u5206\u5b50\u751f\u7269\u5b66\u673a\u5236\u4e86\u89e3\u4e0d\u591a\uff0c\u4e00\u822c\u8ba4\u4e3a\u5176\u53d1\u75c5\u53ca\u6108\u5408\u8fc7\u7a0b\u6709\u591a\u79cd\u56e0\u5b50\u53c2\u4e0e\uff0c\u4e34\u5e8a\u4e0a\u6cbb\u7597\u4e3b\u8981\u4ee5\u6d88\u708e\u3001\u6b62\u75db\u3001\u9632\u8150\u3001\u4fc3\u8fdb\u6108\u5408\u7b49\u5bf9\u75c7\u6cbb\u7597\u4e3a\u4e3b\u3002\u8bb8\u591a\u7814\u7a76\u8bc1\u660eEGF)\u53ca\u5176\u53d7\u4f53EGFR\u5728\u635f\u4f24\u9ecf\u819c\u91cd\u5efa\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u3002\u5b59\u7b49\u5728\u53e3\u8154\u590d\u53d1\u6027\u963f\u5f17\u4ed6\u6e83\u75a1\u7ec4\u7ec7 (RAU)\u4e2d\u53d1\u73b0EGF\u3001EGFR\u8868\u8fbe\u660e\u663e\u51cf\u5c11\u3002\u5eb7\u590d\u65b0\u6db2\u662f\u4e34\u5e8a\u4e0a\u5e7f\u6cdb\u5e94\u7528\u7684\u4e2d\u836f\u5236\u5242\uff0c\u5bf9\u53e3\u8154\u6e83\u75a1\u6709\u826f\u597d\u7597\u6548\uff0c\u80fd\u4fc3\u8fdb\u8089\u82bd\u7ec4\u7ec7\u751f\u957f\uff0c\u4fc3\u8fdb\u8840\u7ba1\u65b0\u751f\uff0c\u52a0\u5feb\u574f\u6b7b\u7ec4\u7ec7\u8131\u843d\uff0c\u8fc5\u901f\u4fee\u590d\u5404\u7c7b\u6e83\u75a1\u53ca\u521b\u4f24\u521b\u9762\uff0c\u5bf9\u5176\u4f5c\u7528\u673a\u5236\u7814\u7a76\u8868\u660e\uff0c\u5eb7\u590d\u65b0\u6db2\u80fd\u4fc3\u8fdbEGF\u3001EGFR\u8868\u8fbe\u3002<\/p>\n<p><span style=\"color: #3366ff;\">4\u3001EGF\u4e0e\u8870\u8001<\/span><\/p>\n<p style=\"text-align: left;\">\u4e3a\u4e86\u7814\u7a76\u8870\u8001\u662f\u5426\u5f71\u54cdEGF\u7684\u751f\u6210\uff0cChou JS\u7b49\u6d4b\u5b9a\u4e86\u4ece\u5a74\u5e7c\u513f\u5230\u8001\u5e74\u7ec4\u4e0d\u540c\u4eba\u7fa4\u7684\u5c3f\u6db2\u4e2dEGF\u7684\u542b\u91cf\u53d8\u5316\uff0c\u7ed3\u679c\u8868\u660e\u5a74\u5e7c\u513f\u7ec4EGF\u5c3f\u6db2\u4e2d\u542b\u91cf\u6700\u9ad8\uff0c\u8001\u5e74\u7ec4\u4e2d\u7684\u6700\u4f4e\uff0cEGF\u751f\u6210\u968f\u7740\u5e74\u9f84\u589e\u957f\u9010\u6e10\u4e0b\u964d\u3002\u845b\u5fd7\u534e\u7b49\u901a\u8fc7\u5927\u9f20\u8870\u8001\u6a21\u578b\uff0c\u68c0\u6d4b\u53d1\u73b0\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u8870\u8001\u5927\u9f20\u4e0b\u988c\u4e0b\u817a\u4e2dEGF\u3001EGFR mRNA\u7684\u542b\u91cf\u660e\u663e\u4e0b\u964d\uff0c\u8bf4\u660e\u8870\u8001\u80fd\u591f\u5f71\u54cdEGF\u3001EGFR\u8f6c\u5f55\u3002Iwasa H\u7b49\u5728Caenorhabditis elegans\u4e2d\u53d1\u73b0HPA-1\u3001HPA-2\u80fd\u7ed3\u5408EGF\u6216EGFR\uff0c\u5c06\u8fd9\u4e24\u4e2a\u57fa\u56e0\u901a\u8fc7RNA\u5e72\u6270\u964d\u4f4e\u8868\u8fbe\u540e\uff0c\u80fd\u964d\u4f4e\u8870\u8001\u5f15\u8d77\u7684\u8fd0\u52a8\u80fd\u529b\u4e0b\u964d\uff0c\u51cf\u5c11\u8272\u7d20\u79ef\u7d2f\uff0c\u5ef6\u957f\u5bff\u547d\u3002<\/p>\n<p style=\"text-align: center;\"><img decoding=\"async\" class=\"aligncenter\" style=\"box-shadow: #979899 0px 0px 10px; border: 1px solid #979899; border-radius: 0px;\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/12\/EGF-5.png\" \/><br \/>\n<span style=\"color: #595959;\">Fig5. HPA-1\u3001HPA-2\u8c03\u63a7\u7ebf\u866bEGF\u4fe1\u53f7\u901a\u8def\u6a21\u5f0f\u56fe<\/span><\/p>\n<h4><span style=\"color: #3366ff;\">EGF\u3001EGFR\u9776\u70b9\u836f\u7269<\/span><\/h4>\n<p><span style=\"color: #3366ff;\">1\u3001\u6297\u764c\u836f\u7269<\/span><\/p>\n<p>EGFR\u7a81\u53d8\u662f\u764c\u75c7\u53d1\u751f\u7684\u91cd\u8981\u56e0\u7d20\uff0c\u76ee\u524d\u4ee5EGFR\u4e3a\u9776\u70b9\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5242\u53ca\u6297\u4f53\u836f\u7269\u7684\u7814\u7a76\u5f88\u591a\u3002\u4ee5\u6297\u4f53\u4e3a\u4f8b\uff0c\u76ee\u524d\u4e0a\u5e02\u7684EGFR\u6297\u4f53\u836f\u7269\u5305\u62ec\u8010\u6614\u59a5\u73e0\u5355\u6297\uff08Necitumumab\uff09\u3001\u5e15\u5c3c\u5355\u6297\uff08panitumumab\uff09\u3001\u897f\u59a5\u6614\u5355\u6297\uff08Cetuximab\uff09\u7b49\uff0c\u8fd9\u4e9b\u5355\u6297\u836f\u7269\u4e0eEGFR\u7ed3\u5408\u540e\u80fd\u963b\u6b62EGFR\u4e0eEGF\u7b49\u914d\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u6291\u5236\u4e0b\u6e38RAS-ERK\u7b49\u4fe1\u53f7\u901a\u8def\u6fc0\u6d3b\uff0c\u8fd8\u80fd\u591f\u4fc3\u8fdb\u5185\u8d28\u7f51\u5e94\u6fc0\u53cd\u5e94\uff08ER stress\uff09\uff0c\u4fc3\u4f7fER\u86cb\u767d\u8f6c\u8fd0\u81f3\u7ec6\u80de\u819c\uff0c\u8fd8\u53ef\u80fd\u5f15\u8d77\u53d7\u4f53\u5185\u5728\u5316\u548c\u88ab\u7834\u574f\u3002EGFR\u6297\u4f53\u4e0eEGFR\u7ed3\u5408\uff0c\u80fd\u5c06\u80bf\u7624\u7ec6\u80de\u5468\u671f\u963b\u6ede\u5728G1\u671f\uff0c\u51cf\u5c11S\u671f\u80bf\u7624\u7ec6\u80de\u6570\u76ee\uff0c\u5f15\u8d77\u80bf\u7624\u51cb\u4ea1\u7b49\u6700\u7ec8\u8d77\u5230\u6cbb\u7597\u764c\u75c7\u7684\u529f\u80fd\u3002\u9664\u4e86EGFR\u6297\u4f53\u5916\uff0cEGFR\u6291\u5236\u5242\u4e5f\u6709\u5f88\u591a\uff0c\u5982\u5409\u975e\u66ff\u5c3c\uff08Gefitinib\uff09\u3001\u76d0\u9178\u5384\u6d1b\u66ff\u5c3c\u7247\uff08Erlotinib HCl\uff09\u3001\u62c9\u5e15\u66ff\u5c3c\uff08Lapatinib\uff09\u7b49\uff0c\u8fd9\u4e9b\u6291\u5236\u5242\u4e3b\u8981\u6291\u5236EGFR\u6fc0\u9176\u6d3b\u6027\uff0c\u6291\u5236EGFR\u81ea\u78f7\u9178\u5316\uff0c\u963b\u6b62\u80bf\u7624\u7ec6\u80de\u751f\u957f\u3001\u8f6c\u79fb\u5e76\u4fc3\u8fdb\u5176\u51cb\u4ea1\u3002<\/p>\n<p><span style=\"color: #3366ff;\">2\u3001\u521b\u4f24\u4fee\u590d\u53ca\u6e83\u75a1\u6cbb\u7597\u836f\u7269<\/span><\/p>\n<p>EGF\u7531\u4e8e\u5177\u6709\u4fc3\u8fdb\u7ec6\u80de\u86cb\u767d\u751f\u6210\u3001\u7ec6\u80de\u589e\u6b96\u3001\u7ec6\u80de\u8fc1\u79fb\u5206\u5316\u7b49\u529f\u80fd\uff0c\u53ef\u7528\u4e8e\u7ec4\u7ec7\u521b\u4f24\u4fee\u590d\u53ca\u53e3\u8154\u6e83\u75a1\u3001\u80c3\u6e83\u75a1\u7b49\u6cbb\u7597\u3002\u5e38\u89c1\u7684\u6cbb\u7597\u6d88\u5316\u9053\u6e83\u75a1\u7684\u4e2d\u836f\u65b9\u5242\u5982\u534a\u590f\u6cfb\u5fc3\u6c64\u3001\u9ec4\u8fde\u6e29\u80c6\u6c64\u3001\u9ec4\u82aa\u5efa\u4e2d\u53e3\u670d\u6db2\u3001\u5b89\u80c3\u6c64\u7b49\u53ca\u6cbb\u7597\u53e3\u8154\u6e83\u75a1\u7684\u5eb7\u590d\u65b0\u6db2\u80fd\u901a\u8fc7\u4fc3\u8fdb\u7ec6\u80deEGF\u7684\u751f\u6210\u53d1\u6325\u7597\u6548\u3002<\/p>\n<p>\u56fd\u5185\u4ee5EGF\u4e3a\u4e3b\u8981\u6210\u4efd\u7684\u751f\u7269\u5236\u54c1\u6216\u533b\u7597\u5668\u68b0\u4e5f\u6709\u5f88\u591a\uff0c\u5982\u91cd\u7ec4\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u51dd\u80f6\u3001EGF\u4fdd\u6e7f\u4fee\u590d\u7cbe\u534e\u819c\u3001\u91cd\u7ec4\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u884d\u751f\u7269\u53ca\u4e00\u6b21\u6027\u4f7f\u7528EGF\u751f\u7269\u6d3b\u6027\u6577\u6599\u7b49\u7b49\uff0c\u8fd9\u4e9b\u4ea7\u54c1\u80fd\u591f\u7528\u4e8e\u521b\u4f24\u4fee\u590d\u53ca\u6e83\u75a1\u6cbb\u7597\uff0c\u4e34\u5e8a\u4e0a\u5e94\u7528\u5e7f\u6cdb\u3002\u751f\u7269\u5316\u5986\u54c1\u884c\u4e1a\u4e2dEGF\u4f7f\u7528\u91cf\u5927\uff0c\u9762\u819c\u3001\u4fee\u590d\u6db2\u3001\u4fee\u590d\u971c\u7b49\u5404\u79cd\u4ea7\u54c1\u4e2d\u6709\u6dfb\u52a0\uff0c\u4f46\u662f\u4e0d\u540c\u7684\u5316\u5986\u54c1\u751f\u4ea7\u5546EGF\u539f\u6599\u6765\u6e90\u4e0d\u540c\uff0c\u6d3b\u6027\u5355\u4f4d\u5b58\u5728\u5dee\u5f02\uff0c\u5bfc\u81f4EGF\u5316\u5986\u54c1\u5e02\u573a\u6bd4\u8f83\u6df7\u4e71\uff0c\u6d88\u8d39\u8005\u8d2d\u4e70\u65f6\u9700\u8981\u614e\u91cd\u6311\u9009\u3002<\/p>\n<p><span style=\"color: #595959;\">\u53c2\u8003\u6587\u732e<\/span><\/p>\n<p><span style=\"color: #595959;\">1. \u9ad8\u4e91\uff0c\u9648\u5609\u660c\uff0c\u6731\u632f\u5b87\uff0c\u5f6d\u7115\u7389\u3002<em>EGFR<\/em>\u57fa\u56e0\u7a81\u53d8\u53ca\u5176\u68c0\u6d4b\u65b9\u6cd5\u7684\u7814\u7a76\u8fdb\u5c55\u3002\u5206\u5b50\u8bca\u65ad\u4e0e\u6cbb\u7597\u6742\u5fd7\uff0c2011\u5e741\u6708\u7b2c3\u5377\u7b2c1\u671f\u3002<\/span><\/p>\n<p><span style=\"color: #595959;\">2. Sreenath V. Sharma, Daphne W. Bell, Jeffrey Settleman and Daniel A. Haber. Epidermalgrowth factor receptor mutations in lung cancer.<\/span><\/p>\n<p><span style=\"color: #595959;\">3. \u5cb3\u5360\u78b0\uff0c\u6768\u589e\u660e\u3002\u8868\u76ae\u751f\u957f\u56e0\u5b50\u4e0e\u54fa\u4e73\u52a8\u7269\u751f\u6b96\u7684\u5173\u7cfb\u3002\u52a8\u7269\u5b66\u6742\u5fd7\uff0c1998\uff0c33\uff083\uff09\u3002<\/span><\/p>\n<p><span style=\"color: #595959;\">4. \u8042\u662d\u534e\uff0c\u90d1\u6587\u5c27\uff0c\u90ed\u8363\u658c\uff0c\u674e\u77e9\uff0c\u5f20\u654f\uff0c\u795d\u6768\u3002\u6d88\u5316\u6027\u6e83\u75a1\u60a3\u8005Hp \u80c3\u7c98\u819c\u708e\u75c7\u548c\u8840\u6e05\u80c3\u6db2EGF\u53d8\u91cf\u7684\u5173\u7cfb\u3002\u534e\u4eba\u6d88\u5316\u6742\u5fd7\uff0c1998\uff1b6(7)\uff1a600\u2014602\u3002<\/span><\/p>\n<p><span style=\"color: #595959;\">5. \u5b59\u9e4f\uff0c\u5f20\u5efa\u5f3a\uff0c\u5218\u658c\uff0c\u95eb\u9896\uff0c\u4ed8\u5c0f\u5175\u3002EGF\u53caEGFR\u5728\u53e3\u8154\u590d\u53d1\u6027\u963f\u5f17\u4ed6\u6e83\u75a1\u4e2d\u7684\u8868\u8fbe\u7279\u5f81\u53ca\u610f\u4e49\u3002\u89e3\u653e\u519b\u533b\u5b66\u6742\u5fd7\uff0c2003\u5e7411\u6708\u7b2c28\u5377\u7b2c11\u671f\u3002<\/span><\/p>\n<p><span style=\"color: #595959;\">6. Chou JS, Reiser IW, PorushJG. Aging and urinary excretion of epidermal growthfactor. Ann Clin Lab Sci. 1997 Mar-Apr; 27(2):116-22\u3002<\/span><\/p>\n<p><span style=\"color: #595959;\">7. \u845b\u5fd7\u534e\uff0c\u674e\u4fca\u73ab\uff0c\u5b59\u7acb\u65b0\uff0c\u674e\u4fca\u9896\uff0c\u5468\u9752\u4e91\u3002\u5b9e\u9a8c\u6027\u8870\u8001\u5927\u9f20\u4e0b\u988c\u4e0b\u817a\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53ca\u5176mRNA\u7684\u8868\u8fbe\u3002\u73b0\u4ee3\u9884\u9632\u533b\u5b66\uff0c2013\uff0c40(15)\u3002<\/span><\/p>\n<p><span style=\"color: #595959;\">8. Iwasa H, Yu S, Xue J, Driscoll M. Novel EGF pathway regulatorsmodulate C. elegans healthspan and lifespan via EGF receptor, PLC-gamma, and IP3R activation. Aging Cell. 2010 Aug; 9(4):490-505.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\">\u25c6\u4e0a\u6d77\u6676\u8bfa\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8\u25c6<\/p>\n<p style=\"text-align: center;\">\u4e25\u683c\u7684\u8d28\u63a7\u4f53\u7cfb<\/p>\n<p style=\"text-align: center;\">\u6210\u719f\u7684\u86cb\u767d\u8d28\u8868\u8fbe\u548c\u7eaf\u5316\u5e73\u53f0<\/p>\n<p style=\"text-align: center;\">\u5e76\u6709\u7ec6\u80de\u56e0\u5b50\u751f\u7269\u5b66\u6d3b\u6027\u68c0\u6d4b\u5e73\u53f0<\/p>\n<p style=\"text-align: center;\">\u4e3a\u60a8\u63d0\u4f9b\u9ad8\u7eaf\u5ea6\u3001\u9ad8\u7ec6\u80de\u751f\u7269\u5b66\u6d3b\u6027\u7684<\/p>\n<p style=\"text-align: center;\">\u7ec6\u80de\u56e0\u5b50\u86cb\u767d\u4ea7\u54c1<\/p>\n<p style=\"text-align: center;\">\u4ee5\u521b\u65b0\u7684\u6280\u672f\u548c\u4f18\u8d28\u7684\u4ea7\u54c1\u7aed\u8bda\u4e3a\u60a8\u670d\u52a1<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-40988\" src=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/11\/\u7ec6\u80de\u56e0\u5b50\u5e7f\u544a.jpg\" alt=\"\" width=\"688\" height=\"1200\" srcset=\"https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/11\/\u7ec6\u80de\u56e0\u5b50\u5e7f\u544a.jpg 688w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/11\/\u7ec6\u80de\u56e0\u5b50\u5e7f\u544a-200x349.jpg 200w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/11\/\u7ec6\u80de\u56e0\u5b50\u5e7f\u544a-86x150.jpg 86w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/11\/\u7ec6\u80de\u56e0\u5b50\u5e7f\u544a-172x300.jpg 172w, https:\/\/www.gene-optimal.com\/wp-content\/uploads\/2018\/11\/\u7ec6\u80de\u56e0\u5b50\u5e7f\u544a-587x1024.jpg 587w\" sizes=\"(max-width: 688px) 100vw, 688px\" \/><\/p>\n<p>\u8054\u7cfb\u6211\u4eec<\/p>\n<p>\u4e0a\u6d77\u6676\u8bfa\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/p>\n<p>\u7535\u8bdd\uff1a0757-29328131-616<\/p>\n<p>\u624b\u673a\/\u5fae\u4fe1\uff1a13392273325<\/p>\n<p>Q Q\uff1a2775427010<\/p>\n<p>\u4e1a\u52a1\uff1ainfo@gene-optimal.com<\/p>\n<p>\u62db\u8058\uff1ahr@gene-optimal.com<\/p>\n<p>\u5730\u5740\uff1a\u5e7f\u4e1c\u7701\u4f5b\u5c71\u5e02\u4f5b\u5c71\u65b0\u57ce\u5cad\u5357\u5927\u90532\u53f7\u4e2d\u6b27\u4e2d\u5fc3A\u680b\uff08\u5206\u516c\u53f8\uff09<\/p>\n<p>\u5b98\u7f51\uff1awww.gene-optimal.com<\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"background-color: #ebf5ff; color: #3366ff; font-size: 10pt;\">\u7248\u6743\u58f0\u660e\uff1a\u672c\u6587\u7cfb\u6676\u8bfa\u751f\u7269\u7f16\u8bd1\u6574\u7406\uff0c\u672a\u7ecf\u6676\u8bfa\u751f\u7269\u6388\u6743\uff0c\u4e0d\u5f97\u8f6c\u8f7d\u548c\u4f7f\u7528\uff0c\u5982\u9700\u83b7\u53d6\u6388\u6743\uff0c\u8bf7\u8054\u7cfb\u6211\u4eec\u3002<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>EGF\u7b80\u4ecb 20\u4e16\u7eaa60\u5e74\u4ee3\u521d\uff0cMontalcin&#8230;<\/p>\n","protected":false},"author":1,"featured_media":41086,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"_links":{"self":[{"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/posts\/41051"}],"collection":[{"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/comments?post=41051"}],"version-history":[{"count":1,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/posts\/41051\/revisions"}],"predecessor-version":[{"id":41085,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/posts\/41051\/revisions\/41085"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/media\/41086"}],"wp:attachment":[{"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/media?parent=41051"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/categories?post=41051"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/tags?post=41051"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}